and Ammonium Bromides on Metabolism. 157 
action was still apparent as was also increased elimination of urea, 
and to a slight extent of uric acid likewise. Indeed, the most notice- 
able effect of the bromide, next to its diuretic action is its decided 
influénce on proteid metabolism as shown by the increased elimina- 
tion of urea. As to phosphoric acid the results are not so striking, 
although an average of the two series shows a diminished excretion, 
both of total P,O, and of P,O, in combination with alkali-earths. The 
average difference in the two series of results is clearly shown by 
the following table: 
Average of Table 
No. I, without KBr. No. Il, with KBr. 
Motaliquantityy on urine 2.2 5ees. eee 926 ¢. ¢. HOMOFexe: 
Syd. (CRSA pS AEs Sh A Se ere eee ee 1025, 8 1026, 3 
Rotalesolid: matters 2250 4_ 2. se seek 56°7329 grams. 63°6252 crams. 
Metal Ope Ss Sos ole sce OM 2°7540 2°5426 
*. P.O; in combination with Ca'and Mg. —-0-6022 0°5452 
(Ofte: Exerc |e eee pe des pee Begs eee 0°6752 0°6858 
TiccyE Da Rae rn a 34-8681 35-9454 
Our results therefore plainly indicate, that under the influence of 
potassium bromide, nitrogenous metabolism is increased while the 
excretion of phosphoric acid is slightly diminished in amount; not 
however, to any such extent as would be expected by an active 
hypnotic agent. The bromide taken, the largest doses about 10 
grams per day, produced its usual physiological effects; such as drow- 
Siness, diminution of the circulation with accompanying coldness and 
paleness of the skfn. Constipation was not noticed while taking the 
bromide, but later on it became somewhat troublesome, once or twice 
alternating with a slight diarrhcea. In accord with Dr. Bill, we no- 
ticed an increase in the acidity of the urine while taking the bromide, 
as also a deepening of the color. 
With bromide of potassium therefore, our results agree with those 
of Dr. Schulze in showing an increased excretion of nitrogen (urea 
and uric acid), although far more pronounced than he found in his 
experiments, while the diminution in phosphorus is less pronounced 
than found by Schulze. 
With Dr. Bill’s experiments our results agree in so far as the 
diminution of phosphoric acid is concerned, but are entirely different 
as regards the urea. Since, however, Dr. bill retained uniformity in 
diet only during the days of the experiments, it is quite possible 
that lack of nitrogenous equilibrium may have had some influence on 
his results. The increased elimination of urea noticed in our experi- 
ments is certainly indicative of increase! metabolic activity ; it is, 
