However this may be, the use of ammonium bromide in our 
experiments gave rise to more unpleasant symptoms than the use of 
like amounts of the corresponding potassium salt. Like the potas- 
sium salt, ammonium bromide caused increased acidity in the urine 
and a brighter color. As to its influence on metabolism, a study 
of Table No. IV, and comparison with No. III, plainly shows a 
decided accelerating influence on the excretion of urea; the average 
of the results, moreover, shows a very slight diminution in the excre- 
tion of total phosphoric acid, at the same time it would appear, in 
accord with what was observed with potassium bromide, that the 
diminution was greatest with the smallest amounts of bromide, as on 
May 9th and 10th and on the 13th and 14th after withdrawal of the 
bromide. With the largest amount of ammonium bromide, on the 
other hand, phosphoric acid appeared to be increased in amount, 
thus according with what Dr. Bill observed with like quantities of 
potassium bromide. 
The average difference in the two series of results is shown by the 
following table: 
164 Chittenden and Culbert—Influence of Potassium 
: 
: 
Average of 
Table No. III No. IV 
without (NH4)Br. with (NH4)Br. 
Total quantity of urine -....----..-- 915 c. c. 1072 ¢. ¢. 
Splert. ete Wek bo Eee pete 1024, 8 1024, 4 
Total solidtmatterss-.. -=.-2-.-- 4.-- 54'3970 grams. 62°3608 grams. 
Total sPrOpeeeesneeant eee eee ees 2°5643 2°5130 
P.O; in combination with Ca and Mg. 074972 0°5749 
Wriclacid\ 2-6 ooo chee goes toe 0°6599 06751 
Wrea lio cee ce pe meant 32°8579 34°6505 
It is thus seen that diuretic action is even greater with the ammo- 
nium salt than with potassium bromide; likewise the excretion of 
both urea and uric acid is greater under the influence of ammonium 
bromide than in the case of the potassium salt; as to phosphoric acid 
the table of averages shows practically nothing, but as before ob- 
served a study of the individual results does indicate some action of 
the salt, although diminution in the excretion of phosphoric acid 
under the influence of ammonium bromide cannot be so surely claimed 
as with the potassium salt. 
After withdrawal of the ammonium bromide, the urine was exam- 
ined for two days more; the results showing the same, or even greater 
drop in the excretion of urea, observed under like conditions with the 
potassium salt (Table No. V.). Hence, so far as our experiments ex- 
tend, the’ influence of the two salts on the metabolism of the body is 
very much alike, differing only in extent of action; the ammonium 
