172. = Chittenden and Whitchouse—Influence of Cinchonidine 
of cinchonidine on the elimination of urea continues to be felt 
after discontinuing the use of the alkaloid; thus even three days 
after the last dose of cinchonidine, the elimination of urea is 6 
per cent. less than in the normal urine. On the fourth day it 
is nearly back to the normal amount [see Table No. II.], and on 
the fifth and sixth days the excretion of urea rises somewhat above 
the average. Uric acid does not appear to be correspondingly 
affected. It is only under the influence of the largest doses, or 
rather under the long continued action of the alkaloid that the ex- 
cretion of uric acid is diminished; thus on May 14th, when the final 
dose of 50 grains of cinchonidine sulphate was taken, the excretion 
of uric acid was for the first time diminished ; its diminution, how- 
ever, was very perceptible and it continued for the two succeeding 
days, after withdrawal of the alkaloid salt. Phosphoric acid was 
greatly diminished in amount under the influence of cinchonidine; 
the diminution commencing to show, as in the case of urea, with the 
first dose of the alkaloid salt, then gradually increasing in amount 
with increase in the dose of cinchonidine until maximum diminution 
was reached on the day after the final dose of the alkaloid. The 
alkaloid salt, moreover, appears to have had a slight diuretic action. 
On the 21st of May, cinchonidine sulphate was again taken, the 
results of the analyses of the 19th and 20th showing that the urine 
had returned to its normal composition. Accordingly, 95°8 grains of 
the salt were taken on the 21st and 22d, producing the same results 
(Table No. IIL.) as noticed in the first series, viz: diminution in the 
amount of urea and uric acid excreted, a like diminution in the amount 
of phosphoric acid and an increase in the total amount of fluid. 
Table No. [V. shows the average results under the different condi- 
tions of the experiments. | 
It is evident then, that cinchonidine has the power of lessening very 
materially the elimination of nitrogen, i. e. the consumption of tissue. 
Ranke* first pointed out the retarding influence of quinine on the 
elimination of uric acid. Zuntz found by experiment upon himself 
that 25 grains of quinine reduced his elimination of urea nearly 40 
per cent. A like diminution in the excretion of urea, under the in- 
fluence of quinine, was noticed by Rabuteau in experiments upon 
dogs and also by Hermann von Boeck.t{ The most interesting ex- 
periments, however, with quinine are those carried out by Dr. G. 
* Quoted from Dr: H. C. Wood, Therapeutics, p. 74, 
+ Zeitschrift fiir Biologie, vol. vii, p. 422. 
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