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Sulphate on Metabolism. - 178 
Kerner,* and more recently by Dr. Priorft and Dr. Sassetzky.{ In 
Dr. Prior’s article isto be found a very complete account of the liter- 
ature of the subject. Dr. Kerner found that taking 9°3 grains of 
quinine hydrochloride per day in divided doses, for 3 days, making 
a total of 27-9 grains, caused a diminution in the excretion of urea, 
amounting on an average for the three days to 12 per cent., while the 
excretion of uric acid under like conditions was diminished 54 per 
cent. Phosphoric acid, too, was diminished somewhat; on an aver- 
age about 4 per cent. per day. Diuretic action was very slight. 
With larger doses of quinine; 77°5 grains of the hydrochloride in 
divided doses during three days; diuretic action was quite pro- 
nounced, the average increase in volume, amounting to 200 c.e. 
Moreover, urea was diminished on an average 23 per cent. per day, 
uric acid 82 per cent. and phosphoric acid 15 per cent. Oppenheim,§ 
however, by a dose of 30°8 grains of quinine found an increase in the 
daily excretion of urea amounting to 4 grams, and he considers that 
Kerner’s results are due to diminution of digestive action. It is cer- 
tain that both quinine and cinchonidine do interfere with the pro- 
teolytic action of the gastric and pancreatic juices,|| but this retarding 
action can hardly be taken as explaining in full, the results obtained 
by Kerner or those obtained by us with cinchonidine. 
Prior, moreover, by very carefully conducted experiments with 
quinine, has completely corroborated Kerner’s results and has shown 
in addition, by a daily determination of nitrogen in the feces, that 
diminution of urea and uric acid is not due to lack of digestive 
action, as suggested by Oppenheim. Prior’s results show on an aver- 
age, without reference to the size of the dose, the following effects 
of the quinine.4 
Quantity of Uric Sodium Sulphuric Phosphoric 
urine. Urea. acid, chloride. acid. acid. 
increase decrease decrease _ decrease decrease decrease 
10°65 per cent. 19°60 % 12°29 % 9°06 % 33°70 % 23°38 % 
Sassetzky’s results with fever patients, also corroborate Kerner’s 
statements. 
* Pfliiger’s Archiv, vol. iii, p. 104. 
+ Ueber den Einfluss des Chinin auf den Stoffwechsel des gesunden Organismus. 
Pfliiger’s Archiv, vol. xxxiv, p: 237. 
{ Ueber den Einfluss fieberhafte Zusténde und Antipyretischer Behandlung auf 
den Umsatz der stickstoffhaltigen Substanzen und die Assimilation stickstoff-haltiger 
Bestandtheile der Milch. Virchow’s Archiv, vol. xciv, p. 485. 
§ Pfliiger’s Archiv, vol. xxiii, p. 476-477. 
| Chittenden and Allen; Chittenden and Cummins. Trans. Conn. Acad., vol. vii. 
§] Pfliger’s Archiv, vol. xxxiv, p. 263, 
