Sulphate on Metabolism. 175 
be seen that cinchonidine has a far less pronounced specific action on 
the excretion of uric acid than quinine, while on the other hand, 
diminution of phosphoric acid is much more pronounced with cincho- 
nidine than with quinine. In Prior’s experiments, however, with qui- 
nine, diminution of phosphoric acid is more pronounced. 
Is this diminution in the excretion of phosphoric acid under the 
influence of cinchonidine to be attributed simply to decrease of pro- 
teid metabolism, or is it in part due to a special action of cinchoni- 
dine on the metabolism of some phosphorized principles, presumably 
those of nerve tissue? If due to general decrease of proteid meta- 
bolism, we might expect to find that the addition of any non-nitro- 
genous principle to our fixed diet, whereby the decomposition of 
albuminous matter would be diminished, would cause a corresponding 
decrease in the excretion of phosphoric acid, or in other words that 
diminution of urea and phosphoric acid excreted, would be in the 
same ratio as noticed under the influence of cinchonidine. 
This question we have endeavored to answer by a study of the 
influence of pure glucose on the elimination of urea, uric acid, and 
phosphoric acid, under the same conditions of diet etc., as observed 
in the experiments with cinchonidine. 
The influence of carbohydrate food on proteid metabolism has been 
illustrated in many ways by various investigators, but so far as we 
know, no experiments with pure glucose have ever been tried. 
Through the courtesy of Dr. Arno Behr, of Chicago, we have been 
supplied with an abundance of chemically pure anhydrous glucose, 
which we have used in the following experiment. Before taking the 
sugar, the urine was analyzed for ten consecutive days, to insure an 
accurate average of the normal excretion under the conditions of the 
experiment. The results are shown in Table No. V. 
200 grams of glucose were then taken daily in addition to the 
fixed diet, for nine consecutive days. The effect on the excretion of 
urea, etc., is shown in Table No. VI. At no time was sugar to be 
detected in the urine by Trommer’s test. A comparison of the two 
tables shows the usual effects of carbohydrate matter on the excre- 
tion of nitrogen, viz: a diminution in the amount of both urea and 
uric acid. The volume of the fluid excreted, appears to be consider- 
ably lessened by taking the glucose. The excretion of phosphoric 
acid is likewise diminished. 
