282 Chittenden and Blake—Distribution of 
3:10 p. m., solution injected. 
3:16 ‘* vomited copiously. 
3:20 <* i again, simply mucus. 
pinoy) << = mucus and bile. 
Sopa te and purged. 
3:45 ‘ partially paralyzed. 
3:04 ‘ vomited again. 
4:30 ‘* much prostrated. 
BlO, 2 “dead: 
The various organs were then separated and the absorbed antimony 
determined, according to the method already indicated. Following 
are the results : 
Sh per 100 
Total weight, Weight of Sb, grams of tissue, 
grams. milligrams. milligrams. 
eiven: feel. ues! Ui seat ety 52°0 6°35 12°21 
Branly cents See ene. Se 275 0°60 2°18 
Heart-and lungs]. -2 2 iee. 32°0 0°70 2°18 
Kap ney Se ono io eas eee 12:0 0:15 1:25 
Stomach and intestines _-_-_-__- 74:0 0:80 1:08 
Mus@le from back -___.-.__-_- 138-0 1°25 0°90 
339°5 9°85 
These figures show the greatest absorption by the liver; the brain 
stands next, while the muscle tissue appears to have absorbed but a | 
relatively small amount of the antimony. In’this connection it must 
be remembered that two hours only, intervened between the intro- 
duction of the poison and the death of the animal, hence it is evident ° 
that the brain tissue must have a decided tendency to hold absorbed 
antimony. The antimony, however, was introduced in the form of a 
readily soluble salt and under conditions directly favoring rapid and 
wide-spread distribution. That there is certainly some decided selec- 
tive action, is evident from the fact that the muscle tissue, which 
must truly have had as good an opportunity as the brain tissue, 
retained per 100 grams of substance far less of the poison. Elimin- 
ation had evidently commenced, for the kidneys contained a decided 
amount of antimony. 
ExpERIMENT II. 
Hypodermic injection of a solution of tartar emetic. 
In this experiment, a smaller amount of tartar emetic was used 
than in the preceding; and further, the poison was introduced in 
three distinct doses, thus allowing longer time for absorption. In 
fact, the animal lived 22 hours after the first dose, hence the experi- 
a 
