Antimony in the organs and tissues. 283 
ment stands in striking contrast to No. 1, in which the animal lived 
but two hours; while the results, contrasted with the- preceding, 
show plainly the influence of time on the distribution of the poison. 
Following are the results of the experiment on a rabbit weighing 
1295 grams. 
Mar. 31, at 5:20 p.m., injected under the skin of leg, 0-012 grm. tartar emetic. 
April 1, ‘* 8:45a.m., a6 és 0:035 ut 
April 1, ‘‘12:45 p.m., gs ae 0-035 ec 
Total, 0:082 
Animal died at 3:05 p. m. 
Following is the distribution of the antimony: 
Sb per 100 
Total weight, Weight of Sb, grams of tissue, 
grams. milligrams. milligrams. 
HRNENOVAS S52 Soe eS oY ee 11°5 0-60 5°21 
1 LATS ps a eae a alg (ee es dle 63:0 1:50 2°58 
STALE awe eee a eee ie 9-0 0:20 2°22 
Stomach and intestines___-_- 98-0 2-00 2°04 
Heart and lungs ___.._------ 17:0 0°25 1:47 
Muscleitronm back 2.2 -.- 2.222 106-0 0°70 0°66 
304°5 5°25 
As might naturally be expected, the results indicate a more 
even distribution of the poison than in the preceding experiment. 
Although two-thirds as much antimony was used as in experiment 
No. 1, the liver contains a far smaller proportional amount of the 
poison than in the preceding experiment, while the ‘kidneys stand 
first in their content of antimony. Between the brain and the liver, 
there is but little difference and the experiment plainly substantiates 
the preceding in showing the tendency of brain tissue, under these 
conditions, to absorb and retain antimony. In the muscle tissue the 
percentage of absorbed antimony is almost exactly the same as in 
No. 1, that is, proportional to the amount of antimony introduced. 
The animal had evidently lived long enough to admit of a fairly 
complete distribution of the poison, and elimination having been 
going on for some time, those parts which had originally contained 
the most, particularly the liver, had been drawn on to the greatest 
extent; so that at the time death intervened, the excretory organs, 
notably the kidneys, were the richest in poison. This fact further 
indicates that the elimination of absorbed antimony proceeds some- 
what rapidly. 
