284 Chittenden and Blake—Distribution of 
Experiment III. 
Hypodermic injection of a solution of tartar emetic. 
In this experiment, a cat weighing 1613 grams, had injected under 
the skin of its hind leg 0°150 gram of tartar emetic in one dose. 
There was some purging and vomiting, and the animal died in 4} 
hours after the administration of the poison. The object sought in 
this experiment, which is virtually a repetition of No. 1, with a some- 
what larger dose of antimony, was simply to see whether there 
would be found the same relative absorption of antimony by the 
liver and kidney as in No. 1, and if by chance there should occur a 
longer interval of time between the introduction of the poison and 
death, what then would be the relative amounts of antimony in the 
two organs. As stated above, the animal lived 4} hours after the 
administration of the poison, or 2} longer than the cat in No. 1. 
Following are the results of the analysis of the two organs: 
‘ Sb per 100 
Total weight, Weight of Sb, grams of tissue, 
grams. milligrams. milligrams, 
Li hic] eee = en Ree ee Seon 62:0 2°50 4-03 
Kidneys 22-2828 220. see 14:5 0°25 1:72 
These confirm to a certain extent the results of No, 1, while at the 
same time the smaller difference between the amount of antimony 
contained in the liver and kidneys, as compared with the difference 
found at the end of two hours (see experiment I), would seem to 
indicate that the liver had already absorbed its maximum amount, 
and that at the time of death, elimination was well under way; or in 
other words, that the removal of the absorbed antimony from the 
liver had already commenced. 
EXPERIMENT IV. 
(a.) Hypodermic injection of a solution of tartar emetic, 
(b.) Injection of a solution of tartar emetic per rectum. 
These two experiments were undertaken to ascertain whether the 
avenue by which the poison was introduced, would influence materi- . 
ally the relative absorption of the antimony. The results, however, 
although interesting, do not definitely answer the question. Absorp- 
tion by injection per rectum is so much slower than by hypodermic 
injection, or the effects produced are so much slower in manifest- 
ing themselves, that it is impossible to have the conditions exactly 
alike in the two cases, Either the time required to produce a given — 
