286 Chittenden and Blake—Distribution of 
Comparing first, the results obtained from rabbit (a) with those 
of the three preceding experiments, we see at once that the distribu- 
tion of the antimony is much the same as in No. 2, in which, how- 
ever, the animal lived nearly 22 hours after the introduction of the 
first dose of poison and somewhat over two hours after the last. 
The fatal dose, moreover, in this case was nearly the same in amount 
as the first dose in experiment IV a. 
The conditions, however, of this experiment (IV @) do not exactly 
accord with any of the preceding, hence close comparisons cannot 
well be made. The brain, as in all of the experiments with tartar 
emetic, contains a proportionally large amount of antimony, while 
the muscle contains a very small amount. The only thing in this 
experiment not exactly in accord with the preceding experiments, is 
the proportionally large amount of poison in the kidneys, as com- 
pared with the liver. The only apparent explanation seems to be 
that, the first dose being small, the liver had quickly reached its 
maximum absorption and elimination had been rapidly going on; so 
that at the end of the four hours intervening between the first and 
second doses of the poison, the kidneys had drawn extensively from 
the liver, rapidly diminishing its content of the poison. Further, 
after the second dose of poison, the time before death was so short 
that the additional absorption by the liver was not sufficient to make 
up the deficiency, and hence the results found. In this connection, it 
must be remembered that tartar emetic is very readily soluble and 
diffusible, and that being injected in solution directly under the skin, 
its absorption must necessarily be very complete and rapid. 
In Rabbit () the conditions are wholly different from those of the 
preceding experiments. In all, 0-24 gram of tartar emetic, dissolved 
in water was introduced into the rectum and 8-10 hours, at least, 
must have intervened between the administration of the first dose of 
the poison and death. That the stomach and small intestines should 
contain the largest proportional amount of antimony is perhaps not 
at all strange, since the antimony solution would naturally pass 
rapidly by osmosis through the entire alimentary tract. That this, 
however, is not the full explanation, is evident, when we compare 
the amount found in the large intestine with the former. If due 
simply to osmosis, the percentage amount of antimony would be 
about the same all through the intestines; hence we must. look to 
some selective action for explanation of the increased amount found 
in the small intestines. In all of the preceding experiments, the 
amount of antimony found in the stomach and intestines has been 
