288 Chittenden and Blake—Distribution of 
EXPERIMENT V. 
(a.) Tartar emetic in substance, introduced into the stomach. 
(.) Antimonious oxide (Sb,O,) introduced into the stomach. 
In this experiment there were two objects in view; one was to see 
the effect of tartar emetic in substance, as compared with the action 
of the same salt introduced into the system by hypodermic injection 
or per rectum; the second, to compare the absorption of an insoluble 
compound of antimony (Sb,O,) with that of the more soluble tartrate. 
In this experiment two dogs were used and the poison was fed to 
them at regular intervals, in small doses, for a period, in each case, of 
17 days. The animals were then killed and the various parts anal- 
yzed.. The two experiments were exactly alike in every respect, 
except in the amount of poison administered. 
(a.) Dog weighing 7°75 kilos was fed 0°762 gram of tartar emetic 
during a period of 17 days, in two or three doses daily, the individ- 
ual doses being small enough not to induce vomiting. The first two 
days, the dose was 0°016 gram per day, the third 0-020 gram, the 
fourth 0-030 gram and so on, increasing each day until the last daily 
dose was 0°085 gram of the poison. The dog was then killed by 
chloroform, just six hours after the last dose of poison was adminis- 
tered. | 
(0.) Dog weighing 14°2 kilos was fed 2°073 grams of antimonious 
oxide, during a period of 17 days, in two daily doses of from 0°032 
to 0°125 gram per day. The dog was then killed by chloroform, 18 
hours after the last dose of antimony was given. 
Following are the results of the analysis of the various parts: 
Doe (a) with tartar emetic—(0°762 gram). 
Sb per 100 
Total weight, Weight of Sb, grams of tissue, 
grams. milligrams. milligrams. 
PaVeIe Ee ete ol ee ae 304 17°80 5°85 
Salivary clamcds,s-oeeo=: 22s se 11 0°25 2°27 
RGM y SU Leilene ley SET E ete 58 1:25 2°15 
Bmaiina f Peps Fk poh got serene el edie 76 1:15 1°51 
LOMOUO [24 eae Sees pepe da 36 0°40 144 
Marseles(Ghie) eee eee ee a ee 150 1°60 1:06 
PPIOEN eS een eee tek eee “29 0°15 0°80 
HieGarh 22) se ere 77 0°50 0°66 
Tine See eee: ee en 140 0°50 0°36 
Bone (femur and tibia)----.--- 43 0:10 0:23 
Bloode. center sea. Lobes 130 0°20 0°15 
Westese cc co- Sena eat a eee 12 trace 
IPANCTOAS G. -eeee tee =- 2eces 28 trace 
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