Ne) 
Antimony in the organs and tissues. 28 
Doe (6) with antimonious oxide—(2'073 grams). 
Sb per 100 
Total weight, Weight of Sb, grams of tissue, 
grams. milligrams. milligrams. 
nivel eee same ee cee oe 452 23°70 5°24 
Arena rg oe ee a RES AER EL _. 140 1°80 1°28 
Muscle (fore leg) _------------ 157 1:20 0-76 
[Bnaineameere hoc n8 54224 52 79 0°40 0-50 
Musclei(Ghigin): a3 2-ss sta. 200 0:90 0:45 
IKGIAM OY Sessa to eee Ss eo 0-10 0°12 
[BIGR VARS ee sos eee ee oe 117 trace 
JELLO aegis Le al de te 440 trace 
1667 28°10 
In considering these results, we notice first that in dog (a) the dis- 
tribution of the poison is much the same as in the preceding experi- 
ments with tartar emetic, viz: the liver, kidneys and brain stand 
first in their content of antimony. That the liver should contain 
more per 100 grams than the kidneys, although the animal lived full 
eight hours after the last dose of poison was taken, is here to be 
expected, since absorption as a whole would naturally be slower 
than in some of the preceding experiments; and, further, in this case 
probably all of the antimony would be absorbed through the portal 
circulation. In the case of dog (6), the conditions are different from 
any heretofore; we have here an insoluble form of antimony con- 
trasted with a readily soluble and diffusible salt. Solution must 
necessarily be somewhat slow in this case, but the acid juices of the 
stomach unquestionably do dissolve and render diffusible, at least a 
portion of, this form of the poison. 
We notice first that the total amount of antimony administered, is 
fully three times as much as the amount of tartar emetic given, and 
yet the amount of antimony recovered from the different tissues and 
organs is but 4 milligrams more than in the case of tartar emetic. 
This suggests that either considerable antimony is excreted by the 
kidneys (more than in the case of tartar emetic) or else that consid- 
erable passes through the alimentary tract unabsorbed. The dog 
being confined in a cage of suitable construction, the 24 hours’ urine 
was collected on several occasions and the amount of antimony deter- 
mined. Thus on one day, when 0:097 gram of antimonious oxide had 
been administered, following after a daily dose of 0:064 gram, the 24 
hours’ urine contained 13°5 milligrams of antimony (Sb). Later, at a 
time when the daily dose was 0°130 gram of the oxide, the 24 hours’ 
urine contained 22°5 milligrams of antimony. Hence it is plain that 
TRANS. Conn. AcapD., Vou. VII. 37 Nov., 1886. 
