300 Chittenden and Blake—Influence of Antimonious Oxide, ete. 
crease in the latter is always accompanied by an increase in the two 
former. In the grand average of the results, however, the slight in- 
crease in nitrogen is not accompanied by a corresponding increase in 
sulphur. In fact, the two series of results, indicate plainly that the 
antimony was without any material action. The total amount of an- 
timony given, 16 grains of the oxide during 13 days, was certainly 
sufficient in quantity to have exerted its peculiar influence if possessed 
of any. The antimony was certainly absorbed, and that too in con- 
siderable amount. Thus on the 11th of June the 24 hours’ urine con- 
tained 13°5 milligrams of metallic antimony; on the 17th, 22°4 milli- 
grams; on the 18th, 17°6 milligrams and on the 20th of June, 15:1 
milligrams of metallic antimony. These quantities of absorbed anti- 
mony would certainly indicate the presence of sufficient antimony for 
some decided influence on metabolic action, if any existed. The 
amount of nitrogen excreted daily, is seen to be considerably below 
the amount of nitrogen ingested. We did not make daily examina- 
tions of the fecal matter, but such as were made showed plainly that 
the deficiency in nitrogen was contained mainly in the feces; thus on 
the 5th of June the 100 grams of feces excreted, contained 2°42 
grams of nitrogen. At that date, the average amount of nitrogen 
excreted by the urine was 12°36 grams per day ; this amount, added . 
to the fecal nitrogen makes a total of 14°78 grams excreted, against 
15°25 grams ingested; a difference to be found mainly in the hair 
thrown off, and in part, in the ordinary errors of analysis. 
We must conclude, therefore, that small repeated doses of anti- 
monious oxide are without influence on the excretion of nitrogen, 
sulphur and phosphorus, and that consequently this compound, at 
least when taken in non-toxic doses, has no action on proteid meta- 
bolism. 
