and Inorganic Substances on Gas Metabolism. 411 
A study of the first results shows plainly a decided action on the 
part of the uranium salt. The influence of the salt, however, mani- 
fests itself somewhat slowly, and it is not until the third day that its 
action becomes very pronounced, when the increased excretion of car- 
bonic acid becomes very noticeable, accompanied with a slight rise 
in temperature. The first action of the uranium appears to cause a 
diminution in body temperature and in the amount of carbonic acid 
eliminated. The total amount of uranium salt given was quite large 
(1:175 grams in divided doses), and although no especial toxic symp- 
toms showed themselves, the animal died on the day following the 
conclusion of the experiment. 
A second series of experiments was tried, using smaller amounts 
of uranium nitrate and extending through four days, the results of 
which are also shown in the accompanying tables. The rabbit was 
~ deprived of food for four days prior to commencing the experiment. 
The amount of uranium nitrate given was considerably smaller than 
the quantity employed in the first series of experiments, and the 
animal did not suffer any permanent iH effects from its use. The 
following table shows the average daily result, expressed in milli- 
grams of CO, contained in the 37°5 litres of aspirated air, together 
with the average body temperature. 
May 3. 38°9° C. 574°3 milligrams CO, 
ger 4. 39-0 540°8 : e¢ 
Ca 39°9 581°2 He «6 
coal; 38°5 716°3 ss ue 
The uranium nitrate was introduced by hypodermic injection in 
the following quantities : 
May 3. 0 
mez: 5:18 p. m. ’ 0:080 gram of the salt. 
ia De 8:40 a. m. 0-090 * fg 
Ata 10:20 a. m. 0:100'  “* -¢ 
oe Os 12:40 p. m. 07150‘ or 
cee 0: 3:25 p. m. (eiles (eres es 
SS say 5:15 p. m. 0200.4" se 
BG. 0 
0-770 
In this second series of experiments it is to be noticed that the first 
two days are given up wholly to determining the normal excretion of 
carbonic acid, and the results show fully how close an agreement 
may be expected under normal circumstances. Taking the results 
