418 Chittenden and Cummins—Influence of some Organic 
of these two days for comparison, it is seen that the action of the 
uranium is somewhat slow, but that it produces on the first day 
(May 5) a noticeable rise in temperature, without any appreciable 
change in the elimination of carbonic acid. The full effect of the 
uranium, however, shows itself on the day following the last dose 
of the salt, and we then see the same noticeable increase in the elim- 
ination of carbonic acid noticed in the first series of experiments. 
We have to conclude, then, that uranium nitrate, when taken in 
sufficient quantity, tends to raise materially the body temperature 
and to increase very noticeably the excretion of carbonic acid. 
Action of cupric sulphate. 
Falck, as quoted by Dr. H. C, Wood,* has found that cupric sul- 
phate acts upon dogs, pigeons, rabbits and similar animals as an 
irritant, neurotic poison; producing great depression of temperature, 
with progressive general paresis ending in death, apparently from 
failure of respiration. Our experiments on rabbits show a marked 
influence of the salt in depressing body temperature and a still 
greater influence in diminishing the production of carbonic acid. 
The results of one experiment are shown in the preceding table. 
Although but 130 milligrams of the copper salt were used altogether, 
the animal finally died on the day following the conclusion of the 
experiment. 
Action of arsenious oxide. 
C. Schmidt and Stiirzwaget have shown by experiments on cats, 
that arsenious acid tends to produce a noticeable diminution in the 
excretion of both nitrogen and carbonic acid. Voit, however, has 
pointed out that in these experiments, the diminished excretion de- 
pends simply on the loss of a large portion of the food by vomiting, 
and Bolckt has shown that small doses of arsenious oxide given to 
hungry dogs, is wholly without influence on the decomposition of 
proteid matter. With large, toxic doses of arsenic, Gihtgens§ and 
Kossel|| have shown that a very noticeable increase in the elimina- 
tion of nitrogen takes place. These facts constitute about the sum 
* Therapeutics, Materia Medica and Toxicology, p. 46. 
+ Moleschott’s Untersuchungen, vi, p. 283. 
+ Zeitschrift fir Biologie, vii, p. 430. 
§ Centralblatt f. Med. Wissen., 1875, p. 529. 
|| Archiy. f. exper. Path. u. Pharm, v, p. 128. 
