428 Chittenden and Cummins—Influence of some Organic 
Jarge dose of morphine sulphate was given, and given by hypo- 
dermic injection. In this case, as before, there was no increased 
muscular activity, but there was a sudden and rapid fall both in tem- 
perature and in the amount of carbonic acid excreted, the latter of 
which was stili quite pronounced on the following day, although the 
temperature has gone back to normal. This diminution in carbonic 
acid was accompanied by a profound narcotism, the animal lying 
almost motionless and with a respiration ranging from 8 to 20 per 
minute. The results, which are to a certain extent corroborative 
of Boeck and Bauer’s, are shown in the accompanying table: 
SECOND SERIES OF EXPERIMENTS WITH MORPHINE. 
Normal period without morphine sulphate. 
' 
A ' 
i i ao © : 2, ; 
Oxalic acid to if gos > 3 & si S 
neutralize ba- = 3) $e é = Sj 2 
ryta solution.| «5 |5S S A | z 
Time aS |SN S| rg 2 ee | eB 
; Es ie) orn > aS 3g 
Pat ace s+ an) qj 3 os] oD 5 
= 2 3 oud ro) faS) oO it.. as aa 
fas} aea(cd) 1 —< HO “= op eats 
Sas i Co Oo = bo 
oo |oSo| $s Sl H's we af So 
Gis 12-8 5171S ia = oO iS) e) 
iB S ~ o) a) o io) ea 
March 12. 
A.M. ; 
9:12 to 9:42 15.4 | 34:1 | 49°5 159°251 9°75 180°6 465°0 | 39-1 
10:00 A. M., injected subcutaneously 0:100 gram morphine sulphate. 
A. M. | 
10:23 to 10:53 | 16-9) 34:5 | 51-4 59:25 785 | 145-4 | 363°5 | 366 
11:29 to 11:59 | 17:3 | 34°5 | 51°8 59:25, 7-45 | 1880 | 3425 | 34-4 
12:32 to 1:02 | 16:3 | 34:1 | 50:4 | 59-25) 8-85 | 1640 | qro‘o | 333 
Pow 
9:48 to 3:18 | 17-0 | 34:2) 51-2 |59-:25| 8:05 | 149°2 | 373°0 | 34:4 
3:49 to 4:19 | 17°8 | 34:6 | 52:4 |59-25| 685 | 126-9 | 317°3 | 85°0 
4:47 to 5:7 =| 17-1 | 34:3 | 51-4 | 59-251 7°85 | 145-4 | 3635 | 363 
March 13. | ; 
10:08 to 10:38 16°9 | 34°3 51°2 | 59°25 8:05 149°2 373°0 39°2 
Action of quinine sulphate. 
The importance of quinine as a therapeutic agent and particularly 
its value as a febrifuge has led to a thorough study of its physiolog- 
— a 
eS 
