436 Chittenden and Cummins—Influence of some Organie 
In the second series of experiments, smaller doses of quinine were 
employed, so that no special toxic action was observed. In this case 
there seemed to be a gradual falling off in the amount of carbonic 
acid produced; such a decrease as might be assumed would naturally 
result from diminished proteid metabolism. 
The results are shown in the accompanying tables. 
The body temperature, as determined per rectum did not show any 
change whatever under the influence of this quantity of quinine 
(total dose 1:575 gram of quinine sulphate). There does not appear 
to be any proof that moderate doses of quinine lower the body 
temperature of healthy animals or even man, and Kerner found in 
his experiments that a full dose of quinine given to a healthy man 
would prevent the usual rise of temperature resulting from vigorous 
exercise, but did not affect the temperature under ordinary circum- 
stances. Liebermeister* has also reported that the alkaloid has no 
constant depressing action on the bodily heat in health. 
Two other short series of experiments were tried with quinine, also 
with rabbits in a condition of hunger. In both of these cases the 
quinine was introduced by sub-cutaneous injection in the form of 
sulphate. In both cases there was a slight fall in temperature, 
accompanied with a noticeable decrease in the amount of carbonic 
acid eliminated, directly after injection of the quinine. This effect, 
however, was only temporary, for the temperature quickly rose 
to the normal, and even somewhat above the normal point, while 
the carbonic acid in the third series came quite back to the normal 
and in the fourth series remained only a little way below. 
It would appear, therefore, from our experiments, that in a healthy, 
hungry rabbit moderate doses of quinine sulphate exercise at the 
most only a very slight depressing influence on body temperature, 
and have but a minimum effect on the production of carbonic acid. 
Action of cinchonidine sulphate. 
Previous experiments + on man have shown that cinchonidine has 
the power of lessening materially the elimination of nitrogen, pre- 
sumably through its inhibitory action on proteid metabolism. 
Cinchonidine is supposed to have much the same physiological 
action as quinine and cinchonine, only weaker. Our present experi- 
# Deutsch. Archiv fiir Klinische Medicin, Band iii. 
+ See Chittenden and Whitehouse, Studies from the Laboratory of Physiological 
Chemistry, vol. i, p. 164. 
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