and Inorganic Substances on Gas Metabolism. 437 
ments with the alkaloid, using quite large amounts of the sulphate, 
show a somewhat different action from quinine. Using a large rab- 
bit, without food for three days, and giving it by way of the mouth, 
in gelatin capsules, large doses of the alkaloid, there was a very 
noticeable and constant rise in temperature up to the very time of 
death, accompanied by a slight but gradual diminution in the amount 
of carbonic acid given off. In all, 1°575 grams of cinchonidine sul- 
phate were given; an amount exactly equal to the quinine sulphate 
given in the second series of experiments with quinine. With cin- 
chonidine, however, the rabbit was much prostrated, showed symp- 
toms of tetanic convulsions, and finally died in a vigorous tetanic 
spasm at the end of the second day. 
The results are shown in the preceding table. 
Action of Antipyrine. 
Antipyrine or dimethyloxychinicine has of late been much experi- 
mented with. Among the many statements which we have seen 
recently concerning its action are the following, which are of interest 
in this connection, Arduin* found that 3 grams given to a rabbit 
produced cataleptic stiffness, diminished reflexes, etc., followed by 
violent convulsions. There was also a very marked fall of bodily 
temperature. Anseroff,+ by experiments on animals, found that the 
alkaloid caused an increase of blood pressure and a decrease of inter- 
nal temperature, as shown by a thermometer in the rectum, but a 
considerable rise in the external temperature, sometimes as much as 
12°C. Pavlinoff{ has reported that antipyrine produces a very con- 
siderable quickening of the respiration, while Dr. Walter, of St. 
Petersburg,§ is reported as having found that the alkaloid while 
reducing febrile temperature, also reduces nitrogenous tissue changes ; 
and further, that the assimilation of proteids is materially favored by 
the drug. F. Miiller|| has also found that in fever antipyrine dimin- 
ishes the excretion of nitrogen. Coppola, however, states that in the 
case of a dog, 0°3-0°4 gram of antipyrine was wholly without action 
on its excretion of nitrogen. Coppola has further found that the 
* Abstract in Therapeutic Gazette, 3d series, vol. i, p. 677. 
+ Abstract in Therapeutic Gazette, 3d series, vol. ii, p. 315. 
¢ Abstract in Therapeutic Gazette, 3d series, vol. ii, p. 339. 
§ Abstract in Therapeutic Gazette, 3d series, vol. li, p. 53, 
|| Jahresbericht fiir Thierchemie, xiv, 242. 
4 Jahresbericht fiir Thierchemie, xv, 97. 
