and Inorganic Substances on Gas Metabolism. 439 
alkaloid not only has a noticeable antipyretic action in conditions of 
fever, but also reduces the temperature in healthy organisms. The 
extent of reduction, however, is not great, ranging only from 0:1 to 
0°6 of a degree. Further, the diminution in temperature is to be 
ascribed, according to’Coppola, not to diminished metabolic activity, 
but to increased giving up of heat, due to dilatation of the blood- 
vessels by the antipyrine. Jacubowitsch * also claims for antipyrine 
an inhibitory action on the excretion of uric acid. So far as our 
knowledge extends, however, no experiments have been tried as to 
the influence of this therapeutic agent on the production of carbonic 
acid. 
Our experiments have been confined wholly to rabbits, and those 
in a condition of hunger. In the first series of experiments, during 
the antipyrine period, the alkaloid was given in large and oft-repeated 
doses, in the form of powder, in gelatin capsules, at follows: 
May 25, 8:33 A. M., 0:2 gram antipyrine. 
fe 20; 9:35 Ss Or2p= 88 re 
S25; 10:30“ Ooze FS 
Soe! op pNP yaaa O20 a5 a 
HG ha. 12:27 P. M., (I OG 
oe ey Pati neta O65 = 
da 3:54“ O65 os 
aos 4:51 OrGrs % a 
anaes 5:46“ OsG7 es 
Seu: 8:45 A.M, O26) 9°" 
Gap: O38: «6! Te0S 45 ee 
5:4 
The accompanying tables show the results obtained. At the end 
of the last period of the second day (May 26) respiration was very 
rapid, about 208 per minute, and during that period the amount of 
carbonic acid excreted was larger than in any other. In spite of the 
large dose taken, however, the alkaloid appears to have had no 
special action on the production of carbonic acid, and further, the 
temperature was only very slightly lowered until on the last day, 
just prior to the animal’s death. On the last day of the experiment 
(May 26) the rabbit appeared much prostrated, and at 10.35 a. M. 
was seized with a convulsion, followed soon after by three others, 
dying at 11.30 a, M. 
In the second series of experiments somewhat smaller amounts of 
antipyrine were given, but here, as in the first series, there was no 
* Jahresbericht fiir Thierchemie, xv, p. 444. 
