EXPERIMENTS WITH DEATH CAMAS. 57 



teeth and was uneasy and restless. The pupils were considerably 

 enlarged. At 6.7 a partial paralysis of the respiration was noted. 

 The breathing: was extremely slow and there was considerable chok- 

 ng. At 10.10 the next morning, June 7, it ate food, although spar- 

 ngly. It would walk and run of its own accord and in other ways it 

 afforded proof that it had verj^ nearly recovered. 



At 2.40 the same day 50 grams more of the fresh leaves was offered 

 to the same rabbit. It ate rapidly at first, but soon became dissatis- 

 fied, and although very hungry, it refused to eat more. The exact 

 amount eaten was not determined, nor many of the symptoms noted 

 on account of an accident. A difficulty in the respiration was observed 

 at 2.55, and Mr. Cockrell, who was watching- the animal, thought that 

 the respiratory symptoms were more pronounced after the animal had 

 taken a g-ood drink of water. This trouble was apparent throughout 

 the day. Twenty-five grams of fresh leaves of flowering plants was 

 offered to the same rabbit at about noon on June 8. The weight of 

 the leaves left uneaten when compared with the weight of a check sub- 

 jected to influences even more favorable to evaporation indicated that 

 none were eaten. No further effects were noted except the continued 

 defect in respiration, but the rabbit died during the night, probably 

 from the combined effect of the several feedings. 



E.i:j)eriment 8. — Three hundred cubic centimeters of a water extract, 

 representing 300 grams of the fresh flowering tops and leaves, was fed 

 to a sheep weighing about 65 pounds at 3.15 p. m. June 12. No 

 effect whatever was noted up to 8 p. m. nor on the following day. 



Experiment 9. — The strongly expressed residue from the extract 

 used in the preceding experiment was allowed to stand over night in 

 such an amount of 50 per cent alcohol that after a very slight dilution 

 on the same day 1 cubic centimeter represented 1 gram of the fresh 

 plant. One and one-half cubic centimeters, representing 1^ grams of 

 the fresh plant, was administered hypodermically June 12 to a 40- 

 ounce rabbit. This amount, although small, had a very marked effect, 

 but was not fatal. The result warranted the institution of the two 

 following experiments, which were made with the same extract. 



Experhnent 10. — Three hundred cubic centimeters of the 50 per 

 cent alcoholic extract used in the preceding experiment was fed at 

 12.21 p. m., June 14, to a sheep weighing about 50 pounds. Disre- 

 garding the general symptoms due to alcohol, which were also observed 

 in another sheep that received an equal amount of 47 per cent alcohol 

 at the same time, the prominent characteristic effects "were as follows: 

 At 2.30 there was considerable frothing of green saliva at the mouth, 

 which was accompanied by a gurgling of the throat and very labored, 

 irregular breathing. There were but 12 inspirations a minute and 

 sometimes two attempts at a single one. The pulse was about 160 a 

 minute and strong. At 3.24 the sheep was becoming conscious, but 



