247 



circumstances, pus-corpuscles are, after all that had been said, 

 formed out of the star-shaped corneal corpuscles. But Cohn- 

 heim ^ opposed this assertion, and, supported by new experi- 

 ments, he rose with still greater boldness, and denied, without 

 reserve, any participation of the corneal corpuscles, which he 

 pronounced to be fixed, in the production of pus corpuscles. 



Exudation and Disturbance of Nutrition. 



Tf we want to find our way in the history of tissue-patho- 

 logy, we must face quite independently of the question about 

 the origin of pus, also the history of the knowledge of 

 those changes in tissue which are peculiar to the process 

 of inflammation. I mean, in the first instance, the satura- 

 tion of the inflamed tissue by fluids, exudations, and the 

 nutritional disturbances of the living elements. I have not 

 yet been able to give myself up so deeply to historical re- 

 searches as to find out to whom we have to ascribe the merit 

 of having found out exudation.- The notion that exuda- 

 tion of liquid substances out of the blood into the tissue is a 

 principal sign of inflammation has found, as far as I can see 

 in the authors in my possession, its most important advocates 

 in Bennett and Rokitansky. 



Bennett^ points to an abnormal exudation of blood-fluid, 

 an eff"usion of serum, or an extravasation of blood, as a sure 

 sign of inflammation. 



The occurrences at the vessels themselves did not appear to 

 him to influence the diagnosis of the process, and he expresses 

 himself on the matter as follows : — " But it is only when the 

 latter (exudation) takes place that Ave can state positively 

 our conviction of the presence of inflammation " (p. 38). 

 Kokitansky^ states again that with exudation the process 

 of inflammation is to be considered as complete (p. 178). 

 But when the doctrine of cell formation in such exudations 

 (blastema), based on Schleiden and Schwann, got put into 

 the background, the doctrine of exudation itself soon shared 

 the same fate. It was particularly the knowledge that the 

 non-vascular tissues may exhibit the same disturbances, ch;i- 

 racterising the process of inflammation, as the vascular tissues, 

 which produced this result. 



In England, dating from the researches on cartilage of 

 Goodsir and Redfern, the password " nutritional disturb- 



1 Loc. cit. 



- According to a note by Virchow (' Geschwiilste '), tliis knowledge took 

 its orif^in in England. 



^ ' Treatise on Inflammation.' Edinburgh, 1844. 

 ■• 'Handbuch der allg. path. Anatomic,' 1846. 



