248 



ances " has been spread abroad, and Virchow has given 

 recognition and value to this password. 



Although, during this whole period, the importance of exu- 

 dation for nutritional disturbances was not entirely left 

 out of consideration, yet people gradually accustomed them- 

 selves in studying the pi'ocess of inflammation not to assign 

 any value, to the ])art played by the vessels. 



But through Cohnheim's studies the attention of his col- 

 leagues has been directed again towards the blood-vessels, and 

 even in so high a degree that nutritional disturbances are 

 again put into the background. In the place of liquid exu- 

 dation living-formed elements are introduced ; but, neverthe- 

 less it is a matter originating in the blood that is pointed 

 out here as the essential feature of incipient inflammation. 



The Connectwe-Tissue Theory. 



Another appearance in the sphere of our literature demands 

 our attention, if we w^ant to get clear about the principal 

 questions of tissue-pathology ; I mean the significance of 

 connective tissue in the process of inflammation. 



Virchow^ has represented the connective substances as the 

 source of all inflammatory new formations. These substances, 

 the extensive distribution of which in the organism has be- 

 come known by Reichert's studies, were supposed to be the 

 real seat of all formative phenomena that accompany the 

 process of inflammation. From the point of view of the in- 

 flammation theorist, you need only consider the organism as 

 a framework of connective substances, in which nerves, 

 muscles, and glands, not essential for new formations, are 

 inserted. Virchow has recognised in this connective sub- 

 stance the persistent cells, and from these all-important 

 results were supposed to arise. 



From time to time great breaches were battered into this 

 doctrine. The discovery of Remak and Buhl taught that 

 the epithelial structures are among the sources of new 

 formations, and no theory could be devised which should 

 point out a relationship between epithelial and connective 

 tissue. 



Histologists agree, and Reichert^ and Remak's works ^ 

 have proved clearly by embryological investigation, that the 

 epithelial structures belong to the category of glands. 



The share of epithelium in new formations was nevertheless 



^ Compare 'Haiidbuch der Lehrc von den Geweben,' Leipzig, 1868, 

 p. 35. 



" 'Das Eutwickelungsleben im Wirbelthiere.' Berlin, 1840. 

 ' ' Eulwickelungsj^escliiciite.' Berlin, 1852, 1855. 



