249 



acknowledged, and that of gland-cells decidedly denied. One 

 single voice — that of Holm — which rose in favour of the new 

 formation of liver-cells, had the fate which befalls a paradoxi- 

 cal statement contradicting the prevailing opinion. Virchow^ 

 himself made the breach wider by proving that muscle-nnclei 

 multiply in the process of inflammation. This fact must 

 Aveigh so much the heavier in opposition to his theory, seeing 

 that the whole doctrine of the multiplication of the connective 

 tissue-corpuscles was principally supported by the demonstra- 

 tion of the multiplication of their nuclei. 



As soon as multinuclear cells were found, the expression 

 that the nuclei had multiplied was allowed. It was dif- 

 ferent with the cells. The proof of a multiplication of these 

 could only be given in the case of cartilage. In all other 

 places one was only justified in conjectures, since the pheno- 

 menon was not observed directly. 



Srelkow," indeed, took refuge in considering muscle-cor- 

 puscles as analogous to connective-tissue-corpuscles — a view 

 which has lost all possibility of holding its ground by O. 

 Weber's^ late researches. 



In opposition to the above-named doctrine (Virchow's con- 

 nective-tissue theory), were also Leidesdorf's^ and my own 

 demonstrations, that capillary vessels grow out in the process 

 of inflammation, and that the capillary walls take a share in 

 the parenchymatous inflammation. Our statements had at 

 the time when they were made but little weight indeed in 

 comparison with His's^ emphatic declaration that in the cornea 

 young vessels are formed from outgrowths of corneal cells. 

 The discovery of Eberth, Aeby, and Auerbach, tliat by means 

 of silver injection the cells out of Avhich the ca])illary tube is 

 built up could be demonstrated, was to our disadvantage, but 

 in favour of the connective-tissue theory. But people are 

 beginning to judge more soberly in this question. It is clear 

 that our observation of genesis could not be purely imaginary. 

 Without misjudging the important discovery mentioned 

 above, people nevertheless admit the new formation of 

 vessels according to Leidesdorf and Strieker's observations in 

 inflammation. 



In addition to all these attacks came Cohnheim's discovery 

 that the inflamed tissues are inundated by colourless blood- 

 corpuscles, and all the consequent statements as to new forma- 

 tions of tissue out of such elements. 



^ ' Virchow's Archiv,' vol. x.ix, p. 220. 



* Ibid. 



^ Ibid., vol. xxxix, p. 216. 



■* ' Sit,zuiigsbericlile,'lSr).5. 



' Loc. cit., page 95. 



