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reason that both present an embryonic form, and hence that 

 the former are derived from the blood. 



Any disputation, however, is opposed by the recently 

 demonstrated fact that at the commencement of the process 

 of inflammation hosts of colourless blood-corpuscles leave the 

 circulatory system to be distributed in the tissue. The 

 question -whether pus-corpuscles be derived from the blood 

 need not, then, be kept open any longer. We must now 

 enquire from what other sources pus may be derived. To 

 this question several answers have been given. 



It has been shown that pus-corpuscles themselves may 

 undergo division, and it has been rendered probable that in 

 pri»fuse suppuration the chief mode of origin of pus is to be 

 sought for in this division process. It has, morever, been 

 proved that epithelial cells, partly by division, partly by 

 endogenous growths, may produce a young generation, and 

 also that connective-tissue-corpuscles in the course of the in- 

 flammatory process undergo peculiar changes, which render 

 the probability of the division of these bodies no longer open 

 to doubt, and upon the results of which peculiar changes in 

 the character of pus-corpuscles depends. Finally, it has been 

 proved that the corpuscles of muscle may multiply. 



We can thus in the first place express, as quite a general 

 proposition, " that pus- corpuscles take their origin from various 

 sources." 



The physiological mother tissues which have in this manner 

 given rise to pus-corpuscles must, in respect of their altered 

 function, have been subjected to a quantitatively or qualita- 

 tively altered chemical process. Let us say, in deference to 

 a conception by Avhich so much has been gained for pathology, 

 that some disturbance of nutrition must have taken place. 



It has, moreover, been now proved that the process of in- 

 flammation may result in an outgrowth of capillary vessels, 

 that liver-cells may be transformed into filaments, and also 

 that, under certain conditions, the nuclei of nerve-cells may 

 multiply. All these occurrences likewise indicate disturbance 

 of nutrition, which must be interpreted in the sense of an 

 elevated vital process. For increase in size, change of form, 

 and the appearance of fresh nuclei, are vital phenomena ; and 

 when such are observed where formerly they did not exist, 

 some portion of the vital processes must have been augmented. 

 We see, then, that the process of inflammation is accom- 

 panied by an elevation of certain fuyictions of the cellular 

 elements invoiced in the process. This may be expressed as a 

 general proposition, since the phenomena mentioned have been 

 observed in all cell types. 



