280 J. JACKSON CLARKE. 



of the glands. In the latter situation the accumulated spores, 

 devoid of any containing capsule, had an appearance which 

 recalled the well-known Sarcosporidia — a resemblance which 

 will be referred to again in a subsequent part of this paper. 

 That these small free bodies were swarm-spores derived from 

 the coccidia was shown conclusively, I think, by a close exa- 

 mination of the epithelial cells against which they lay. Many 

 of the cross-sections of the pyloric glands had the appearance 

 shown in fig, 9, where some of the lining cells contain one or 

 several minute bodies, many of the same size and appearance 

 as the small free bodies lying in the lumen of the gland. 



From the minute intracellular parasites which lay in the 

 cell-protoplasm a gradation of forms could be traced up to the 

 encapsuled swarm-sporing parasites ; but in the stomach the 

 full-sized intracellular parasites were very few in number 

 compared with those about to be described in the intestine. 

 This was probably due to the majority of the parasites having 

 subdivided into swarm-spores without the formation of a cap- 

 sule, a process which occurs in C. ov if or me in the acute 

 disease, and which will be described immediately in the small 

 intestine in the mouse. 



Small intestine. — Sections taken from various parts all 

 presented similar features. The epithelial cells of the glands 

 of Lieberkiihn were almost every one infected, and in the 

 majority of them the parasites were spherical with numerous 

 " corps albuminoides de reserve,^' and a small central body 

 which stained with eosin, and in the lumen of the gut lay the 

 encapsuled free parasites. 



Sections of the small intestine showed that there the 

 epithelial cells were as much infested as in the stomach, but 

 the parasites presented a somewhat different aspect, as is 

 shown in fig. 10, which represents a cross-section of one of 

 the crypts. The epithelial cells show signs of having pro- 

 liferated, being in places three deep instead of forming a 

 single layer, and the sickle- shaped swarm-spores are wanting. 

 Most of the intracellular parasites are in the shape of granular 

 spheres, the granules staining with eosin ; but some, such as 



