STUDY OP COOOIDIA MET WITH IN MICE. 281 



the one marked a, have larger granules ^ staining deeply with 

 haematoxylin. One parasite [b) has surrounding it a thick 

 capsule, and is in the same phase as that shown in fig. 1. The 

 granules and the central body took the eosin and not the 

 haematoxylin of tlie stain. Other parasites were larger than 

 this, but still devoid of a capsule (c), and represented, I be- 

 lieve, an intermediate phase between the common form {b) and 

 the phase represented by the bodies d and e, which measured 

 respectively 34 x 19 /i and 35 x 22 /z. The marginal part is 

 represented as seen in optical section, and is marked by a close- 

 set series of short rods which stained a deep blue with haema- 

 toxylin. The lighter dots in the bodies represent the surface 

 rods seen out of focus, and the series of darker dots in their 

 inner parts are represented as seen in focus, though they are 

 placed on the surface of the parasites. I have met with para- 

 sites in this phase in the liver and intestine of rabbits suffering 

 from acute coccidial disease, and as I have nowhere seen a full 

 account of this particular phase, I may introduce two figures 

 (11 and 12) taken from sections of a rabbit's liver. These 

 short rods I believe to be of the nature of chromosomes, and 

 the parasites in this phase to be almost wholly nuclear in con- 

 stitution. I once believed them to be wholly nuclear, until 

 lately, at the suggestion of Professor Marcus Hartog (Cork), 

 I looked for a layer of protoplasm, which I have found to be 

 present, but so thin is this layer that it is difiicult to make 

 out. Some of the modes of subdivision of this phase of the 

 parasite are illustrated in fig. 10, d, and figs. 11 and 12. 



The large intestine contained innumerable coccidia both 

 within the epithelial cells and free, but I could find none in 

 the phase of sickle-formation as in the stomach, nor were there 

 any with peripheral rods as in the small intestine. The liver 

 and kidneys showed no abnormal features. 



1 have not yet been able to procure Eimer's original paper, 

 but it is freely abstracted by Leuckart.^ I have been able to 



' These granules, like those staining with eosin, are in some cases " corps 

 albuniinoides," i. e. stored food material. 



2 Leuckart, 'Parasites of Man,' Hoyle's translation, 1886, pp. 197 and 

 219. 



