Dll. UEALEj ON THE TISSUES. O 



tioii of the nuclei and in tlie matter wliich passes between 

 the nuclei^ being granular and less fibre-like. Such fibres 

 are composed of'Avhite fibrous tissue with its nuclei and their 

 prolongations (formed material and germinal matter). 



The mode of development of these thick cord-like fibres 

 of connective tissue in the cutis of the frog was described. 

 Numerous oval nuclei are seen undergoing division Avhich 

 occurs transversely and longitudinally. The distance between 

 each gradually becomes increased,, and for some time granular 

 matter (which ultimately becomes fibrous tissue) may be 

 seen intervening between one nucleus and the other. 



A tissue, therefore, which possesses the characters of white 

 fibrous tissue may be formed like other tissues from germinal 

 matter, or it may result from changes taking place in tissues 

 which originally possessed much higher endowments. In 

 the last case it may serve as a support to the new texture 

 which is developed, and as life advances this tissue, the 

 debris of more important structures, becomes, in certain 

 localities, more abundant. Although it is true that many 

 very different forms of Avhite fibrous tissue exist, it is interest- 

 ing to observe, in certain cases, the great similarity between 

 the arrangement of the low'est temporary forms of this tissue, 

 of which false membranes are composed, and that of the 

 higher and more permanent forms of the structure, as 

 seen in tendon, fascia, and even the proper tissue of the 

 cornea. 



In prep. 38 might be seen, at one view, some of the 

 youngest portions of the ensiform cartilage of the mouse and 

 its connection with tendon to which muscular fibres arc 

 attached. The matrix of the cartilage is in direct continuity 

 wdth the fibrous tissue of the tendon. Upon a careful ex- 

 amination of this specimen it might be observed that the 

 youngest elementary parts are only separated from each 

 other by a very thin line of formed material, and the ger- 

 minal matter tinted with carmine, seems to shade gradually 

 into the intervening substance. The proportion of formed 

 material between each oval mass, or between the collections 

 of masses of germinal matter, gradually increases towards 

 the outer part. These very important points are most satis- 

 factorily shown in specimens treated with carmine. As in 

 other tissues, the relative proportion of the germinal matter 

 to the formed material of cartilage, gradually becomes less 

 as we pass from the youngest towards the older parts of the 

 tissue, or, in other words, as the elementary parts advance in 

 age. 



A thin section through the tendo xichillis and os calcis (in 



