146 DR. BEALE, ON THE CATTLE PLAGUE. 
Dr. Beale gives full details of the special changes of a 
similar kind in the various secretions and in the alimentary 
tract, but we have not space to give them here. After some 
remarks upon the general increase of germinal matter found 
throughout the tissues of the body, Dr. Beale notices the 
bearing of this matter upon the question of the rise of tem- 
perature so constantly noticed in this and other fevers: 
—“It will have been remarked that the changes which 
I have demonstrated in connection with the germinal matter 
of the tissues generally in fevers precisely resemble those ob- 
served locally in inflammations. In fact, the local phenomena 
of inflammation precisely correspond, up to a certain stage, 
with the general phenomena of fever. The former reach a 
degree to which the latter cannot attain, because, as it is 
scarcely necessary to observe, the death of the man or animal 
must occur long before general suppuration could be brought 
about. 
“ It is remarkable that, while this increase in the germinal 
matter is taking place, the temperature rises some degrees 
above the normal standard, and I think that the elevation of 
temperature in this disease, as well as in fevers and inflam- 
mations generally, can scarcely be due to increased oxidation, 
for both respiration and circulation are often seriously im- 
peded, but attribute it rather to the phenomena occurring 
during the increase of the germinal matter and connected 
with this increase. If this is so, it is probable that an in- 
crease of germinal matter is invariably associated with the 
development of heat.” 
After discussing many other interesting poimts, Dr. Beale 
sums up thus :—‘ Without, therefore, pretending to be able 
to identify the actual materies morbi of the cattle plague, or 
to distinguish it positively from other forms of germinal 
matter present in the fluids on the different free surfaces and 
in the tissues in such vast numbers, I think the facts and 
arguments adduced tend to prove, first, that it is germinal 
matter ; secondly, that the particles are not directly descended 
from any form of germinal matter of the organism of the in- 
fected animal, but that they have resulted from the multipli- 
cation of particles introduced from without; thirdly, that it 
is capable of growing and multiplying in the blood; fourthly, 
that the particles are so minute that they readily pass through 
the walls of the capillaries, and multiply freely in the inter- 
stices between the tissue elements or epithelial cells; and, 
lastly, that these particles are capable of living under many 
different conditions—that they live and grow at the expense 
of the various tissue elements, and retain their vitality al- 
