142 PROCEEDINGS OF SOCIETIES. 
lesion on the part to which they are applied, and impair the 
functional activity of the tissues. ‘But strong as are the ar- 
guments thus obtained by inference, it would be very de- 
sirable to confirm them by direct observation of the tissues. 
It fortunately happens that the pigmentary system of the 
frog is a tissue which, from its peculiar form and colour, is 
very apparent to the eye, so that it is easy to trace the re- 
markably active functions with which it is endowed, and their 
modifications under the influence of irritation.” 
The author concludes: ‘‘Thus, direct observation of the 
structures of the frog’s web which dischargefunctions apparent 
to the eye, furnishes unequivocal support to the inference de- 
rived from other considerations, that in inflammation the 
tissues of the part, the primary seat of the affection, are in a 
state of diminished functional activity.” 
