276 LIONEL JAMES PIOTON. 



minute piuk and greeu granules are found, and also large 

 bright red masses, that probably have some office in connection 

 with the blood-pigment, possibly that of reserve. One more 

 structure remains to be spoken of — the large^, deeply stained, 

 homogeneous granules mentioned above (fig. 5, c). The fact that 

 they most frequently occur in richly granulated places suggests 

 that they are other products of the same activity that gave 

 rise to the granules. And indeed, although their mode of 

 origin is obscure, some cases are found in which they appear 

 to be in a state of formation from the deeply staining portions 

 of several of the crumpled, ovoid bodies. This is at any rate 

 possible, seeing that the chief portions of the latter require to 

 be accounted for, since spherical spaces are often found empty, 

 except for a scrap of degenerating membrane.^ The homo- 

 geneous bodies occur in considerable numbers, and occasionally 

 one is found in the cortex of the organ. 



The reactions of the brown granules serve to differentiate 

 them from the sorts of chloragogen described by Schaeppi. 

 In the following tests for solubility the reagents were applied 

 directly, and not drawn under a cover-slip. Absolute alcohol 

 had but little effect on the granules, except to slightly contract 

 them. After the addition of a saturated solution of oxalic 

 acid to fresh teased tissue, in three or four minutes those 

 granules which naturally contain a central dark spot sur- 

 rounded by a lighter portion had become homogeneous and 

 somewhat reduced in size. There was no further change. 

 When ether is poured over a hand-section of material pre- 

 served in alchol, as evaporation goes on some large yellow 

 drops appear, a pigmented fat having been dissolved out of the 

 tissue. Strong acetic acid, whether cold or boiling, has no 

 effect. The same is true in the case of hydrochloric acid 

 diluted to 50 per cent. Strong hydrochloric acid, on the other 

 hand, dissolves the brown granules in the cold when allowed to 

 stand for some time; boiled on a slide or in a test-tube the 

 granules are at once dissolved by it. Sulphuric acid gives a 



' On the other hand, it is possible that the empty spaces have lost their 

 contents during nianipuhiliou. 



