STKUOTURE OF THE MAMMALIAN GASTRIC GLANDS. 383 



result in an increase of the amount of secretion stored up in 

 the cell. 



Fig. 9 shows a similar gland from the pylorus of an animal 

 killed six hours after a copious meal of meat. The cells are 

 increased in length, and the nuclei exhibit a tendency to become 

 irregular in outline and flattened in a direction at right angles 

 to the long axis of the cell. The portion of the cell between 

 the nucleus and the lumen is now entirely filled up with a 

 coarse meshwork, which stains strongly in indulin, and contains 

 a similarly staining secretion, although in many cells a division 

 of this into two masses, partly separated from one another by 

 a band of protoplasm, is still obvious. 



Fig. 10 is from an animal killed twelve hours after a meal 

 consisting of several pieces of sponge soaked in beef juice. The 

 lumen of the gland is now increased in size, and the cells much 

 shorter than in the preceding phase. The nuclei have regained 

 their spherical shape, and are situated nearer the middle of the 

 cell. The secretion has been nearly all cast out of the cell, so 

 that only an extremely small amount on the free border is now 

 to be recognised. 



The pyloric glands of the cat illustrate in a very striking 

 manner the fact that in gland cells the period of greatest 

 loading does not always coincide with the end of a normal 

 period of rest. Here it appears that the growth that takes 

 place in the cell during the rest period following the comple- 

 tion of digestion results merely in an increase of the proto- 

 plasm of the cell, and that during the first hours of digestion a 

 large portion of this is rapidly transformed into mucigen, so 

 that the real period of greatest loading is reached some hours 

 after digestion begins. 



Further evidence in support of the view that the indulino- 

 philous cells of the neck of the fundus glands and the pyloric 

 gland cells of the cat are identical is afforded by an examina- 

 tion of the short intermediary zone. The first change that 

 one notices in passing from the greater curvature in the 

 direction of the pylorus is an increase of the indulinophilous 

 cells in the body of the gland. At the same time the neck of 



