386 R. R. BENSLEY. 



The secretion phases are represented in figs. 13 and 14. 

 The resting cell (fig. 13) contains already a great deal of 

 reserve secretion, the nnoleus being crescentic and compressed 

 against the base of the cell. In the exhausted phase (fig. 14) 

 the secretion is for the most part confined to the free border 

 of the cell, although many of the cells exhibit spherical masses 

 in the neighbourhood of the now spherical nucleus. The 

 protoplasm is also very much increased in amount. 



All observers are agreed that the fresh pyloric glands of the 

 dog do not contain coarse granules. The only granules that 

 may be observed are small globules of fat, which are 

 particularly numerous in the bases of tiie cells. The mucous 

 secretion of the cell, too, occasionally, as in the cat, precipitates 

 in a granular or flakv form, althousrh I have never observed 

 this in secretions hardened in aqueous sublimate solutions. 

 The protoplasm of the cell contains only a trace of prozymogen. 



Conclusions. 



In the cat and dog the fundus glands contain two kinds of 

 chief cells, those of the body and those of the neck of the 

 gland. The former are engaged in the secretion of ferment, 

 and are characterised by the possession of a large number of 

 zymogen granules which occupy a portion of the cell of varying 

 extent near the lumen, and a protoplasmic outer zone of 

 various size which stains intensely in nuclear dyes such as 

 lisematoxylin, and presents a coarse fibrillar structure. The 

 staining properties of this outer protoplasmic zone are due to 

 the presence in it of a kind of chromatin, which may stand in 

 a genetic relation to zymogen, and which has been named pro- 

 zymogen. 



I regard the cells of the neck of the gland, and the pyloric 

 gland cells in the cat and dog, to be of the same nature, for 

 the following reasons : 



The chief cells of the neck of the fundus gland and the pyloric 

 gland cells do not contain at any period of digestion zymogen 

 in the form of granules, and prozymogen is present only in 

 traces. 



