STRUCTURE OF THE MAMMALIAN GASTRIC GLANDS. 387 



Both groups of cells are engaged in forming and secreting a 

 substance which stains intensely in Bordeaux R, in indulin, and 

 in Mayer's specific mucin stain muchsematein, and which gives 

 the usual metachromatic mucin stain with thionin. 



Both may be traced through a gradual transition to the 

 cylindrical cells of the surface. 



The assertion that the secretion of these cells is mucin rests 

 as yet on the evidence afforded by the structure of the cell, 

 and its staining in thionin and Mayer's rauchsematein. No 

 method has suggested itself to me for securing the secretion of 

 these cells unmixed with that of the surface epithelium, and 

 testing it for mucin. It is, however, on evidence of the same 

 character that the large transparent neck cells of the batra- 

 chian gland have been accepted as mucus-secreting cells. 



The chief cells of the neck of the fundus glands, and the 

 pyloric gland cells of the cat and dog, are the physiological and 

 morphological homologues of the mucous neck cells and pyloric 

 gland cells of the frog, with which they correspond in situation, 

 structure, functional changes, and staining. It is interesting 

 to note that these cells in the frog and other Batrachia stain 

 intensely in indulin when treated with mixtures of eosin, 

 indulin, and aurantia. 



The cells of the lowest portion of the gland duct or pit are 

 of a type intermediate between the surface epithelium and the 

 mucin-secreting neck cells or pyloric gland cells, and form 

 the fundamental type to which the origin of both must be 

 traced. Moreover the researches of Bizzozero ^ have made it 

 extremely probable that these, although themselves secreting 

 cells, are constantly dividing, and so form the young elements 

 from which both the cells of the surface and the neck cells, or 

 the pyloric gland cells, are recruited, although it must be 

 admitted that the two latter are partially replaced by division 

 among themselves. 



Mucin-secreting neck cells are present in the fundus glands 

 of the mink, rabbit, mouse, rat, squirrel, ground hog(Arctomys), 

 chipmonk (Tamias striata), pig, and sheep. The relation 

 ' ' Aicli. f. mik. Anat.,' Bd. xlii. 



