RHINOSPORIDIUM KINEALYI. 529 
operation (1). With more experience, removal of the tumour 
with cauterisation of the base was found to be the best form 
of treatment (2), which shows clearly that unless the parasite 
be extirpated completely, it will multiply and produce fresh 
growths. We are unable, however, to bring forward any 
observations upon the manner in which the spore-morule 
give rise to new generations of parasites. And the method 
by which the parasite succeeds in infecting fresh hosts must 
remain for the present a complete mystery. 
From the preceding summary it is evident that this parasite 
must be placed in, or close to, the sub-class Neosporidia of 
the Sporozoa. The multinucleate trophozoites of irregular 
form; the progressive and continuous spore-formation, com- 
mencing at an early period in the growth of the parasite ; 
the formation of uninucleate pansporoblasts from which 
numerous spores arise; and the intercellular habitat of the 
parasite in the submucous tissue—these are points which are 
diagnostic, or at least characteristic, of the Neosporidia. On 
the other hand, its position in the sub-class is less clear. ‘The 
amoeboid trophozoite and the minute spores recall the poly- 
sporous Microsporidia, but ‘a sharp difference is seen in the 
absence of any pole-capsule in the spores, a feature which dis- 
tinguishes Rhinosporidium from each of the three orders 
at present included in the Neosporidia. Moreover, Micro- 
sporidia are not known to occur in any warm-blooded verte- 
brate, in which class of hosts the Sarcosporidia seem to take 
their place, but it cannot be said that Rhinosporidium has 
any special resemblance to the Sarcosporidia, though this is 
the only group of Neosporidia hitherto known to occur in 
man. Another feature which appears to differentiate Rhino- 
sporidium from the typical Neosporidia is the manner in 
which spores are formed successively in the pansporoblasts. 
In this point it recalls the peculiar but still unnamed parasites 
described by Schewiakoff in Cyclopide (4; see also 38, 
pp. 318-320, fig. 127). The simple nature of the spores, on 
the other hand, recalls the parasites for which Caullery and 
Mesnil have founded the order Haplosporidia, as for example 
vot. 49, PART 3.—NEW SERIES. 39 
