RELATION OF PATHOGENIC TO SEPTIC BACTERIA. 61 



I have had opportunity of using grey mice for my inoculations, 

 and also bastards of white and grey mice, but did not notice 

 any refractory power possessed by the former against anthrax 

 blood. Some observers have noticed a certain amount of re- 

 sistance offered to the anthrax virus by the grey mouse, but 

 in these instances they were wild mice, >vhereas in my cases 

 they were born in captivity and tame. 



At the seat of the inoculation with blood in mice the place 

 is always more or less marked as slightly discoloured and a 

 little tumid, but since death as a rule occurs within thirty-six 

 hours there is not much chance of inflammation. After the 

 inoculation of mice with blood, and the same applies to other 

 anthrax material, as well as to artificially-cultivated anthrax, 

 the animals appear in perfect health until a short time, some- 

 times half an hour or an hour before death ; they are very 

 lively and feed well; nothing in their condition reveals the 

 presence in them of the seed of death, when suddenly they 

 become quiet, their movements become impeded, their breathing 

 rapid, and their temperature begins to sink ; and after half 

 an hour, or even less, sometimes more, up to two hours, they 

 are dead. 



So remarkably sudden is this change from apparent health 

 to a sickness that is rapidly and surely fatal, that this form of 

 the disease has in Germany received the name of ful mini- 

 render Milzbrand, Teufelsschuss (Roll, * Lehrbuch d. 

 Path, und Ther.,' &c., Wien, 1876, i, p. 493). 



In guinea-pigs I noticed on inoculation of blood or any other 

 anthrax material and artificial cultivations into the subcuta- 

 neous tissue of the inguinal region, as a rule before the day is 

 over, a distinct oedematous swelling; this increases gradually 

 till the animal dies, which in the case of blood happens gene- 

 rally within thirty-six or forty-eight hours. Death is also here 

 rapid, but not so rapid as in mice, since the animal becomes 

 quiet and weak several hours before death takes place. On 

 post-mortem examination the subcutaneous tissue of the in- 

 guinal region and abdomen, especially on the side of inocula- 

 tion, shows much oedematous swelling. Near the seat of the 



