57 
is formed by loose clusters of spores in artificial chambers 
bounded by delicate strands of connective-tissue (cham.). 
Outside, again, there are several concentric and partially 
imbricate layers of connective-tissue (con. tis.). The 
comparative looseness of the peripheral layers is partly 
due to the shrinking together of the central residual mass 
on fixation, and also to the fact that, once the “ cyst” is 
in the appendage, any further layer-formation, and, of 
course, the proliferating infiltration, is free to expand. 
From Hagenmiiller’s account it is quite evident that his 
cysts were nothing more or less than a similar modification 
of the infiltrated condition. 
Before passing on to consider the spores, there is an 
interesting point which a comparison of the two types of 
infection, as set forth above, leads me to regard as being 
very probable, namely, the potential independence of the 
pansporoblasts in Glugea (7.e. their capability of existence 
as separate individuals in certain circumstances). 
Stempell (6), p. 263, has already suggested that 
Thelohania, Pleistophora, &e. (those forms where the 
whole individual becomes one reproductive organella), 
are examples of a phylogenetic individualization of the 
pansporoblasts. Now, I am inclined to think this may 
take place normally—for instance, in the condition of 
diffuse infiltration 
as a stage in the life cycle. Quite 
probably * multiplicative reproduction ” is, here, simply 
a separation of the pansporoblast rudiments, as daughter- 
individuals. Indeed, the whole nature of the diffuse in- 
filtration in Glugea seems to me to support this idea. 
There is no question of the individual parasites attaining 
size, still less of any continuity of a protoplasmic mass 
ramifying in and between the host’s tissue-cells. It is 
far rather a cell-infection, visible, when ripe, as sepa- 
rate clumps of spores, each formed from, and 
