4.94, ARMAND RUFFER. 
13, a). Occasionally two or more nuclei of the same cell are 
joined together by a bridge of protoplasm, which stains red, 
whilst in other cases the nuclei become extremely irregular 
(see figs. 11, a, 18, a). In later stages the nuclei lose their 
power of retaining the colouring matter, part of the nucleus 
staining deep red, whilst the remainder is rose coloured or 
yellowish-grey (see figs. 10, 6, c, 11, 6). At the same time 
the protoplasm of the cell becomes of a yellowish-grey colour, 
and looks as if swollen up and increased in size (see fig. 11, ¢, d). 
A later stage is characterised by the fact that the nuclei lose 
their power of retaining colouring matters at all, and form 
small greyish-brown masses (see fig. 11, e, f). Then the nuclei 
finally disappear, and the leucocytes are represented by greyish 
round masses which may or may not contain bacilli in their 
interiors (see figs. 9,a@; 10,d; 11,9; 12, a,6,c; 18,6; 14, a, 6, 
c, d, e, f,g; and 15,a, 6). Many of the degenerated leucocytes 
are surrounded by a clear space or vacuole (see figs. 10, 8, 
13, a). Nuclei ofter appears to offer greater resistance to the 
digestive power of the macrophages, for partially digested 
nuclei of leucocytes are found in these large cells, at a time 
when the remainder of the cell has already disappeared (see 
fig. 10,4,c). These fragments of nuclei are often also surrounded 
by a vacuole (see fig. 10 8). 
Vacuoles now appear in the intracellular dead leucocytes 
(see fig. 10, d), or else the cell looks as if its peripheral parts 
were being slowly eaten away (see fig. 14,h,7). The half- 
digested cells now become very irregular in shape, whilst the 
vacuoles increase in size and number. Lastly, the cells become 
smaller through this process of digestion, more and more irre- 
cular at the same time, and the dead leucocytes are finally 
represented by small masses of dirty-looking yellowish-green 
protoplasm (see figs. 12,e; 18, ¢,d,e; 14,7, 4, l). 
It is impossible to say for certain whether the larger macro- 
phages absorb and digest the smaller ones. But although 
unable to follow the stages of this process, I have often seen in 
the larger cells débris of nuclei, greatly resembling those of 
the small macrophages ; so that this same inclusion and intra- 
