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  FRANCIS 
  H. 
  A. 
  MARSHALL. 
  

  

  period. 
  The 
  same 
  sliape 
  and 
  the 
  same 
  general 
  relations 
  

   between 
  the 
  various 
  layers 
  of 
  tissue 
  are 
  maintained 
  both 
  for 
  

   the 
  two 
  horns 
  and 
  for 
  the 
  body 
  of 
  the 
  uterus, 
  transverse 
  

   sections 
  of 
  the 
  latter 
  having 
  a 
  diameter 
  only 
  slightly 
  longer 
  

   than 
  that 
  of 
  sections 
  cut 
  througli 
  one 
  of 
  the 
  horns. 
  

  

  2. 
  Period 
  of 
  GroAvth. 
  — 
  The 
  beginning 
  of 
  the 
  pro-oestrum 
  

   is 
  marked 
  by 
  the 
  growth 
  of 
  the 
  uterine 
  stroma, 
  which 
  goes 
  

   on 
  until 
  the 
  cavity 
  is 
  reduced 
  to 
  about 
  half 
  its 
  normal 
  size. 
  

   The 
  growtli 
  takes 
  place 
  through 
  multiplication 
  of 
  the 
  stroma 
  

   nuclei, 
  the 
  increase 
  in 
  number 
  occurring 
  for 
  the 
  most 
  part 
  

   regularly 
  throughout 
  the 
  whole 
  tissue, 
  aud 
  not 
  being 
  confined 
  

   to 
  any 
  particular 
  part. 
  As 
  a 
  result 
  of 
  this 
  process 
  the 
  size 
  

   of 
  the 
  uterus, 
  as 
  indicated 
  by 
  the 
  length 
  of 
  the 
  diameter 
  of 
  a 
  

   transverse 
  section 
  through 
  the 
  body 
  or 
  one 
  of 
  the 
  horns, 
  is 
  

   slightly 
  enlarged, 
  the 
  increased 
  thickness 
  of 
  the 
  walls 
  being 
  

   not 
  entirely 
  compensated 
  for 
  by 
  the 
  reduction 
  in 
  the 
  size 
  of 
  

   the 
  cavity. 
  

  

  The 
  multiplication 
  of 
  the 
  stroma 
  nuclei 
  occurs, 
  apparently, 
  

   by 
  direct 
  division, 
  no 
  mitoses 
  being 
  visible. 
  This 
  appearance 
  

   is 
  scarcely 
  due 
  to 
  the 
  method 
  of 
  fixation, 
  since 
  evidence 
  of 
  

   mitotic 
  division 
  can 
  be 
  detected 
  among 
  the 
  cells 
  of 
  the 
  

   epithelium. 
  

  

  The 
  first 
  indications 
  of 
  growth 
  are 
  followed 
  by 
  an 
  increase 
  

   in 
  the 
  size 
  of 
  the 
  blood-vessels. 
  At 
  a 
  slightly 
  later 
  stage 
  

   these 
  also 
  multiply 
  in 
  number, 
  apparently 
  by 
  division 
  of 
  one 
  

   vessel 
  into 
  two. 
  The 
  increase 
  of 
  the 
  vessels, 
  like 
  that 
  of 
  the 
  

   nuclei, 
  occurs 
  fairly 
  equally 
  throughout 
  the 
  stroma. 
  The 
  

   blood-vessels 
  in 
  the 
  surrounding 
  muscular 
  tissue 
  also 
  tend 
  to 
  

   become 
  enlarged 
  and 
  congested. 
  

  

  Before 
  the 
  close 
  of 
  this 
  period 
  the 
  blood-vessels 
  of 
  the 
  

   stroma 
  become 
  still 
  further 
  enlarged 
  and 
  packed 
  Avith 
  cor- 
  

   puscles, 
  while 
  their 
  walls 
  appear 
  stretched, 
  as 
  if 
  preparatory 
  

   to 
  the 
  breaking-down 
  process 
  which 
  characterises 
  the 
  com- 
  

   mencement 
  of 
  the 
  next 
  period. 
  

  

  The 
  epithelium 
  lining 
  the 
  cavity 
  undergoes 
  no 
  material 
  

   change, 
  though 
  cell-division 
  is 
  perhaps 
  somewhat 
  more 
  

   fi-etjuent. 
  The 
  same 
  may 
  be 
  said 
  of 
  the 
  epithelium 
  of 
  tlio 
  

  

  