﻿340 
  FRANCIS 
  H. 
  A. 
  MAKSHAI-L. 
  

  

  me 
  to 
  be 
  untenable, 
  wliile 
  the 
  absence 
  in 
  the 
  ferret's 
  ovaries 
  

   of 
  corpora 
  lutea 
  (or, 
  at 
  any 
  rate, 
  of 
  newly-formed 
  corpora 
  

   lutea^) 
  during 
  the 
  period 
  of 
  desire, 
  an 
  absence 
  resulting 
  from 
  

   failure 
  to 
  ovulate, 
  precludes 
  the 
  possibility 
  that 
  oestrus 
  in 
  

   some 
  way 
  results 
  from 
  an 
  internal 
  secretion 
  of 
  the 
  corpus 
  

   luteum. 
  

  

  It 
  is 
  important 
  to 
  note 
  in 
  this 
  connection 
  that 
  Mr. 
  Heape 
  

   found 
  (1897) 
  that 
  not 
  one 
  out 
  of 
  forty-two 
  menstruating 
  

   females 
  of 
  Semnopi 
  thecus 
  entellus 
  had 
  a 
  recently-dis- 
  

   charged 
  follicle 
  in 
  either 
  ovary, 
  Avhile 
  one 
  only 
  among 
  seven- 
  

   teen 
  individuals 
  of 
  Macacus 
  rhesus, 
  which 
  were 
  menstru- 
  

   ating, 
  had 
  a 
  newly-discharged 
  follicle 
  in 
  one 
  ovary. 
  In 
  this 
  

   case 
  the 
  monkey 
  was 
  passing 
  through 
  a 
  late 
  stage 
  of 
  

   menstruation 
  (the 
  stage 
  of 
  the 
  formation 
  of 
  the 
  menstrual 
  

   clot), 
  while 
  the 
  follicle 
  appears 
  to 
  have 
  been 
  one 
  that 
  had 
  

   very 
  recently 
  ruptured. 
  

  

  There 
  is, 
  however, 
  a 
  considerable 
  amount 
  of 
  evidence 
  

   supporting 
  the 
  view 
  that 
  the 
  pro-oestrum 
  is 
  brought 
  about 
  

   by 
  some 
  kind 
  of 
  ovarian 
  secretion. 
  Thus, 
  it 
  is 
  generally 
  

   stated 
  that 
  if 
  ovariotomy 
  be 
  performed 
  menstruation 
  ceases, 
  

   the 
  small 
  percentage 
  of 
  cases 
  where 
  it 
  has 
  been 
  known 
  to 
  

   continue 
  being 
  accounted 
  for 
  on 
  the 
  supposition 
  that 
  some 
  

   portion 
  of 
  one 
  of 
  the 
  ovaries 
  was 
  not 
  removed. 
  Moreover, 
  

   Glass 
  (Halban, 
  1901) 
  has 
  shown 
  that 
  in 
  the 
  case 
  of 
  a 
  woman 
  

   with 
  whom 
  menstruation 
  had 
  ceased 
  in 
  consequence 
  of 
  

   ovariotomy, 
  it 
  was 
  again 
  induced 
  by 
  the 
  grafting 
  of 
  a 
  new 
  

   ovary. 
  Knauer 
  (Halban, 
  1901) 
  has 
  performed 
  similar 
  opei'a- 
  

   tions 
  on 
  dogs, 
  and 
  similar 
  results 
  were 
  obtained. 
  Halban 
  

   (1901) 
  also 
  found 
  that 
  after 
  i-emoving 
  the 
  ovaries 
  of 
  monkeys 
  

   menstruation 
  ceased, 
  while 
  it 
  continued 
  after 
  a 
  grafting 
  of 
  

   the 
  ovary. 
  Halban's 
  experiments 
  show 
  further 
  that 
  the 
  

   recurrence 
  of 
  menstruation 
  after 
  the 
  latter 
  operation 
  was 
  not 
  

   a 
  purely 
  nervous 
  phenomenon, 
  since 
  it 
  took 
  place 
  when 
  the 
  

   ovary 
  was 
  grafted 
  in 
  a 
  position 
  different 
  from 
  the 
  normal. 
  

   These 
  and 
  similar 
  observations 
  seem 
  to 
  dispose 
  of 
  the 
  view 
  

  

  ' 
  111 
  any 
  case, 
  on 
  Fraenkel's 
  liypotliesis, 
  the 
  occurreune 
  of 
  the 
  pro-oestruin 
  

   seems 
  to 
  be 
  entirely 
  de|)endent 
  n]ion 
  a 
  previous 
  ovulation. 
  

  

  