﻿THE 
  DEVELOPMENT 
  OF 
  FLAGELLATED 
  OKGANISMS. 
  367 
  

  

  On 
  the 
  Development 
  of 
  Flagellated 
  Organisms 
  

   (Trypanosomes) 
  from 
  the 
  Spleen 
  Protozoic 
  

   Parasites 
  of 
  Cachexial 
  Fevers 
  and 
  Kala- 
  

   Azar. 
  

  

  By 
  

  

  L,coiiard 
  Ko^ers, 
  1?I.D., 
  M.R.C.P., 
  I.ITI.S., 
  

  

  Acting 
  Professor 
  of 
  Palliolofry, 
  Medical 
  College, 
  Calcutta, 
  

  

  (With 
  Plate 
  25.) 
  

  

  The 
  small 
  oval 
  parasites, 
  known 
  under 
  the 
  name 
  of 
  

   Leishman-Donovan 
  bodies 
  (although 
  they 
  appear 
  to 
  have 
  

   been 
  first 
  found 
  by 
  D. 
  D. 
  Cunningham 
  in 
  Dehli 
  boil) 
  were 
  

   described 
  last 
  year 
  as 
  occurring 
  in 
  the 
  enlarged 
  spleens 
  of 
  

   patients 
  dying 
  of 
  chronic 
  fever 
  with 
  marked 
  cachexia 
  by 
  

   Leishman, 
  who 
  considered 
  them 
  to 
  be 
  degenerate 
  trypano- 
  

   somes^ 
  because 
  he 
  found 
  somewhat 
  similar 
  bodies 
  form 
  with 
  a 
  

   large 
  and 
  a 
  small 
  chromatine 
  mass 
  in 
  the 
  spleens 
  of 
  rats 
  

   which 
  had 
  died 
  forty-eight 
  hours 
  before 
  of 
  trypanosomiasis 
  

   due 
  to 
  the 
  organisms 
  of 
  tsetse 
  fly 
  disease. 
  Donovan, 
  working 
  

   in 
  Madras, 
  found 
  similar 
  bodies 
  in 
  blood 
  obtained 
  fresh 
  from 
  

   patients 
  suffering 
  from 
  this 
  fever, 
  thus 
  proving 
  that 
  those 
  

   seen 
  by 
  Leishman 
  were 
  not 
  degenerate 
  trypanosomes, 
  and 
  

   Laveran, 
  after 
  examining 
  Donovan's 
  specimens, 
  came 
  to 
  the 
  

   conclusion 
  that 
  the 
  parasite 
  was 
  a 
  piroplasma. 
  Ross, 
  Nuttall, 
  

   and 
  Manson 
  have 
  all 
  dissented 
  from 
  this 
  view, 
  and 
  resfard 
  

   the 
  organism 
  as 
  probably 
  belonging 
  to 
  a 
  new 
  genus. 
  

   Christophers 
  suggests 
  that 
  it 
  is 
  a 
  microsporidium.^ 
  

  

  I 
  have 
  elsewhere 
  shown 
  that 
  the 
  parasite 
  is 
  to 
  be 
  found 
  in 
  

  

  * 
  Professor 
  Ray 
  Lankester, 
  in 
  the 
  ' 
  Quarterly 
  Review,' 
  July, 
  1904, 
  expresses 
  

   the 
  view 
  that 
  Scliaudinn's 
  recently 
  published 
  researches, 
  " 
  On 
  the 
  Trypano- 
  

   somes 
  of 
  the 
  Blood 
  of 
  the 
  Stone 
  Owl," 
  render 
  it 
  probable 
  that 
  Leishman's 
  

   corpuscles, 
  as 
  well 
  as 
  those 
  of 
  Delhi 
  sore, 
  are 
  stages 
  in 
  the 
  life-history 
  of 
  

   a 
  Trypanosoma. 
  

  

  VOL. 
  48, 
  PART 
  3. 
  — 
  NEW 
  SERIES. 
  27 
  

  

  