﻿374 
  LEONARD 
  ROGERS. 
  

  

  Very 
  occasionally 
  groups 
  of 
  three 
  instead 
  of 
  two 
  organisms 
  

   are 
  found 
  botli 
  in 
  the 
  early 
  conjugating 
  stage 
  and 
  in 
  the 
  

   later 
  elongated 
  and 
  flagellated 
  forms, 
  as 
  shown 
  in 
  fig. 
  2 
  of 
  

   line 
  X. 
  

  

  The 
  Trypanosome-like 
  Stage 
  of 
  Development. 
  — 
  

   From 
  the 
  forms 
  so 
  far 
  described 
  all 
  that 
  could 
  safely 
  be 
  said 
  

   is 
  that 
  flagellated 
  organisms 
  with 
  an 
  elongated 
  body 
  and 
  

   micronucleus 
  at 
  the 
  flagellated 
  end 
  have 
  been 
  obtained, 
  but 
  

   it 
  could 
  hardly 
  be 
  called 
  a 
  definite 
  trypanosomo. 
  However, 
  

   the 
  forms 
  shown 
  in 
  line 
  XI 
  of 
  the 
  plate 
  go 
  far 
  to 
  support 
  the 
  

   view 
  that 
  the 
  organism 
  is 
  really 
  a 
  trypanosome, 
  these 
  having 
  

   been 
  found 
  in 
  a 
  one 
  day 
  culture 
  of 
  Case 
  37, 
  in 
  which 
  the 
  

   conditions 
  must 
  have 
  been 
  in 
  some 
  unknown 
  way 
  much 
  more 
  

   favourable 
  to 
  the 
  development 
  of 
  the 
  organism 
  than 
  in 
  the 
  

   other 
  cases. 
  The 
  forms 
  shown 
  in 
  figs. 
  8 
  to 
  12 
  of 
  line 
  XI 
  are 
  

   pi'ecisely 
  like 
  the 
  flagellated 
  forms 
  described 
  above, 
  except 
  

   that 
  they 
  have 
  elongated 
  out 
  to 
  a 
  much 
  greater 
  degree, 
  so 
  as 
  

   to 
  very 
  closely 
  resemble 
  trypanosomes 
  in 
  everything 
  except 
  

   the 
  absence 
  of 
  an 
  undulating 
  membrane, 
  but 
  this 
  is 
  known 
  to 
  

   be 
  absent 
  in 
  very 
  young 
  trypanosomes, 
  so 
  that 
  it 
  would 
  be 
  

   expected 
  to 
  be 
  the 
  last 
  feature 
  to 
  be 
  developed 
  in 
  the 
  growth 
  

   of 
  the 
  organism 
  from 
  the 
  plasmodial 
  spleen 
  form. 
  The 
  

   double 
  forms 
  shown 
  in 
  figs. 
  8, 
  10, 
  and 
  12 
  of 
  line 
  XL 
  are 
  of 
  

   great 
  interest 
  as 
  an 
  indication 
  that 
  these 
  trypanosome-like 
  

   forms 
  have 
  also 
  developed 
  in 
  pairs, 
  as 
  in 
  the 
  more 
  pyriform 
  

   flagellated 
  forms 
  shown 
  in 
  line 
  X. 
  Further, 
  fig. 
  9 
  of 
  line 
  XI 
  

   was 
  one 
  of 
  two 
  precisely 
  similar 
  forms 
  lying 
  close 
  together 
  as 
  

   if 
  they 
  had 
  just 
  separated, 
  as 
  in 
  fig. 
  3 
  of 
  line 
  X. 
  Moreover, 
  

   the 
  figs. 
  2, 
  3, 
  and 
  4 
  of 
  line 
  XI 
  are 
  precisely 
  similar 
  in 
  nature 
  

   to 
  the 
  early 
  stages 
  of 
  Cases 
  47 
  and 
  58 
  already 
  described, 
  

   from 
  which 
  they 
  only 
  differ 
  in 
  the 
  greater 
  elongation 
  of 
  3 
  

   and 
  4. 
  A 
  possible 
  explanation 
  of 
  the 
  more 
  typically 
  try- 
  

   panosome-like 
  appearance 
  of 
  the 
  flagellated 
  forms 
  of 
  Case 
  37 
  

   is 
  that 
  as 
  they 
  developed 
  within 
  twenty-four 
  hours, 
  instead 
  

   of 
  only 
  after 
  three 
  or 
  four 
  days 
  as 
  in 
  the 
  other 
  cases, 
  they 
  

   must 
  have 
  found 
  the 
  blood 
  in 
  which 
  they 
  were 
  growing 
  much 
  

   less 
  altered 
  than 
  it 
  is 
  after 
  several 
  days' 
  incubation 
  in 
  a 
  test- 
  

  

  