﻿THE 
  DEVELOPMRXT 
  OF 
  FLACIELLATED 
  ORGANISMS. 
  375 
  

  

  tube, 
  and 
  consequently, 
  the 
  conditions 
  being 
  less 
  unnatural, 
  

   their 
  development 
  has 
  more 
  nearly 
  approached 
  the 
  typical 
  

   form 
  o£ 
  trypan 
  osomes. 
  

  

  Amoeboid 
  Forms. 
  — 
  The 
  small 
  flagellated 
  forms 
  repre- 
  

   sented 
  in 
  figs. 
  1, 
  5, 
  6, 
  and 
  7 
  of 
  line 
  XI 
  are 
  also 
  of 
  great 
  

   interest, 
  for 
  they 
  correspond 
  veiy 
  closely 
  with 
  the 
  forms 
  of 
  

   Trypanosoma 
  Brucii 
  described 
  by 
  Rose 
  Bradford 
  and 
  

   Plimmer 
  in 
  the 
  ^Quarterly 
  Journal 
  of 
  Microscopical 
  Science' 
  

   of 
  February, 
  1902, 
  as 
  '' 
  amoeboid 
  " 
  stages, 
  and 
  found 
  by 
  them 
  

   in 
  the 
  lungs 
  of 
  animals 
  affected 
  by 
  tsetse 
  fly 
  disease. 
  The 
  

   origin 
  of 
  the 
  flagella 
  from 
  the 
  micronuclei 
  is 
  well 
  seen 
  in 
  

   figs. 
  6 
  and 
  7 
  of 
  this 
  series, 
  which 
  I 
  bave 
  only 
  found 
  in 
  this 
  

   case, 
  although 
  that 
  sliown 
  in 
  fig. 
  5 
  has 
  been 
  met 
  with 
  in 
  

   others 
  as 
  well. 
  As 
  these 
  very 
  delicate 
  organisms 
  do 
  not 
  

   appear 
  to 
  form 
  part 
  of 
  the 
  regular 
  cycle 
  of 
  development 
  of 
  

   the 
  trypanosome 
  stage 
  from 
  the 
  spleen 
  parasites, 
  it 
  appears 
  

   to 
  me 
  to 
  be 
  possible 
  that 
  they 
  may 
  be 
  a 
  portion 
  of 
  the 
  life- 
  

   history 
  of 
  the 
  parasite 
  which 
  is 
  well 
  fitted 
  to 
  live 
  in 
  the 
  

   circulation, 
  and 
  which 
  might 
  conceivably 
  be 
  carried 
  from 
  one 
  

   patient 
  to 
  another 
  by 
  the 
  bites 
  o£ 
  flies 
  and 
  mosquitoes 
  without 
  

   undergoing 
  any 
  development 
  within 
  the 
  insects, 
  just 
  as 
  I 
  

   showed 
  in 
  a 
  previous 
  paper 
  the 
  trypanosoma 
  of 
  surra 
  may 
  be 
  

   cai'ried 
  from 
  one 
  animal 
  to 
  another 
  by 
  the 
  bites 
  of 
  horse 
  flies 
  

   in 
  a 
  purely 
  mechanical 
  manner, 
  an 
  observation 
  which 
  has 
  

   since 
  been 
  confirmed 
  both 
  in 
  South 
  America 
  and 
  in 
  the 
  

   Philippine 
  Islands. 
  In 
  this 
  connection 
  it 
  is 
  worth 
  while 
  re- 
  

   calling 
  the 
  fact 
  that 
  when 
  Indian 
  cattle 
  are 
  inoculated 
  with 
  

   the 
  surra 
  trypanosoma 
  they 
  suffer 
  from 
  only 
  a 
  mild 
  chronic 
  

   form 
  of 
  the 
  disease, 
  and 
  the 
  trypauosomes 
  are 
  only 
  found 
  in 
  

   their 
  blood 
  for 
  a 
  few 
  days 
  after 
  a 
  definite 
  incubation 
  period. 
  

   Nevertheless, 
  they 
  every 
  now 
  and 
  then 
  get 
  attacks 
  of 
  fever 
  

   for 
  many 
  months 
  afterwards 
  (very 
  like 
  the 
  repeated 
  attacks 
  

   in 
  cachexial 
  fever 
  and 
  kala-azar), 
  but 
  trypanosoma 
  can 
  no 
  

   longer 
  be 
  found 
  in 
  their 
  blood 
  at 
  such 
  times 
  by 
  ordinary 
  

   microscopical 
  examination. 
  Nevertheless, 
  I 
  found 
  that 
  if 
  a 
  

   little 
  of 
  their 
  "blood, 
  taken 
  during 
  one 
  of 
  these 
  periodical 
  

   attacks 
  of 
  fever, 
  is 
  inoculated 
  into 
  a 
  susceptible 
  animal 
  they 
  

  

  