430 GEOEGE H, F. NUTTALL. 



in various quarters, it seems eminently desirable to give a 

 brief impartial summary of the experimental work which has 

 been clone, relying solely upon published researches, these 

 being cited in their chronological order. With the facts 

 thus marshalled before him every reader is at liberty to draw 

 his own conclusions. 



The study of the hasmocj^tozoa begins with the discovery 

 by Ray Lankester in 1871 of Drepanidium ran arum. 

 Human malarial parasites were seen, but their significance 

 not comprehended until Laveran published his investigations 

 in November, 1880. Following upon the fundamental work 

 of Laveran, the most important discovery was that of Golgi 

 (November, 1885), who demonstrated the relationship exist- 

 ing between the life-cycle of the parasites within the human 

 body and the occurrence of the febrile attack. With regard 

 to these investigations there has never been any dispute on 

 the question of priority, but this is far from being the case 

 with the discoveries which followed. Any further disputes 

 regarding the priority of subsequent discoveries should be 

 disposed of by such a chronological record as that which 

 follows, in which not only the year, but also the month and 

 even day of publication are given. 



Chronology relating to certain of the more Im- 

 portant Recent Researches on Malaria. 



1893 and 1895, Sacharoff demonstrated the presence of 

 chromatic substance within the "flagella" of 

 certain avian parasites by means of the Romanowsky 

 stain. 



December 17th, 1895, Ross observed the process of 

 ''flagellation " of crescentic parasites to occur in the 

 stomach of mosquitoes (species not determined) fed 

 on the blood of a malarial patient. 



1896, Bignami and Dion is i report the negative results of two experi- 

 ments made in 1893-4 with mosquitoes (species uncertain) collected in 

 malarious localities, the insects being permitted to bite healthy per- 

 sons. They attribute the failure of the experiment to the dispersion of 



