426 M. ARMAND EUFFEE. 



longer takes up colouring matter. Not infrequently one of 

 these cells is contained in a larger cell^ possessing a clear vesi- 

 cular nucleus, which is surrounded by a large amount of some- 

 what coarse protoplasm ; in other words, it is taken into the 

 interior of a typical macrophage. 



Some of the dead lymphocytes contain bacilli which some- 

 times appear healthy, but not infrequently are more or less 

 degenerated. It might be supposed that these cells died owing 

 to the entrance of bacilli into their protoplasm ; many dege- 

 nerated cells, however, are found in which not a single living 

 or dead bacillus is to be seen. These cells probably never 

 contained bacilli, but perished as the result of the toxic influ- 

 ence of the poisons secreted by the micro-organisms surround- 

 ing them. In the chronic form of the disease, therefore, it is 

 possible to follow the struggle of the bacilli and the lympho- 

 cytes, a struggle in which sometimes the former and sometimes 

 the latter perish. It is a noticeable fact that although the 

 animal dies from the inoculation, no micro-organisms penetrate 

 into the tissues ; the bacilli have all been arrested at the point 

 of inoculation, and this arrest is evidently due to the barrier 

 formed by the amoeboid cells at the seat of inoculation. 



Similar facts have been observed in the erysipelas of man, or 

 when the disease is artificially produced in animals by inocu- 

 lation. 



The part of the skin affected with erysipelas may be divided 

 into three zones. The first or peripheral zone, although show- 

 ing no trace of redness, nevertheless contains numerous 

 streptococci lodged in the lymphatic vessels. The second zone 

 looks rather inflamed, and contains many migrating cells, the 

 greater number of which are filled with streptococci. Finally, 

 the third or innermost zone is crowded with snaall round-cells, 

 and contains no streptococci. 



The following facts were observed on seven cases of erysipelas. 

 Two of these cases proved fatal, and in them numerous strepto- 

 cocci were found in the lymphatic vessels, in the skin, and in 

 the layers immediately beneath, but always outside the vessels. 



