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the hypothesis that in the case of avitaminosis an impaired function 
of many organs is caused by a deficiency of a substance, which is 
supposed to be a constituent of “orypan”. We believe that this 
problem is not. yet ripe for solution for the simple reason that only 
few positive facts are known. We only wish to point out that the 
above hypothesis migth be supported by the results of our research. 
CONCLUSIONS. 
When avitaminosis has been elicited in fowls through a polished 
rice diet, or in cats fed on specially prepared meat, the sensitivity 
of the animals to adrenalin, histamin, cholin, and atropin, and the 
sensitivity of the surviving organs of those animals to histamin, 
pilocarpin, atropin and cholin, is unmodified.. 
In two experiments it was proved that atropin (in doses of from 
0,001 mgr. to 1 mgr. added to 75 ce. of Tyrode) had no inhibitive 
effect on the guts of fowls suffering from avitaminosis; these guts 
performed only faint spontaneous movements. The gut of normal 
fowls displayed unmistakable inhibition on the application of atropin. 
In view of Le Heux’s experience of the influence of cholin on the 
inhibitory or the stimulating effect of atropin on the gut, this would 
also lend support to the conception that in hens fed on polished 
rice a stimulating substance in the gut is wanting. 
