BY C. J. POUND, F.R.M.S. Dd 
more particularly tropical countries, by many competent 
observers, notably Laveran, Koch, Lingard, Plimmer, Brad- 
ford, Theiler, Allen Smith, Voges, and Vsigburg. 
The combined labours of these investigators have con- 
firmed the researches of the more early workers on the subject, 
and have published much valuable information concerning 
the hfe histroy of the different species of Trypanosoma, tech- 
nique of the methods for the detection, influence of sex. 
age and breed of the many species of animals that are subject 
to Trypanosomiasis, and also the questions of treatment of 
the disease and immunity. 
In 1902 considerable interest was aroused in the medical 
profession by what may be taken to be a newly discovered 
disease in the human subject, for Dr. J. E. Dutton, of the 
School of Tropical Medicine in Liverpool, demonstrated the 
trypanosoma parasites in the blood of a man who had been 
living in the Gambia colony on the West Coast of Africa. 
Dutton mentions in his report that this patient was first seen 
by Dr. Forde in the Gambia colony in May, 1901, and in his 
blood he found small worm-like extremely active parasites, 
which was subsequently recognised by Dutton as trypanosoma. 
The symptoms presented by the patient were: Irregularly 
intermittent jtebrile attacks, the temperature remaining 
above normal (2 or 3 degrees) for a few days. and then falling 
below normal for a few days; the skin dry, with irregular 
patches of a congested or cyanosed character ; puffy «edema 
of the face, and slightly around and above the ankles, res- 
pirations and pulse altered, being rapid and variable ; heart 
sounds pecuharly muffled: urme and bowel excretions 
practically normal. In the later stages of the complaint 
both hver and spleen were found enlarged. Loss of weight 
and considerable debility, wasting, and lassitude were marked 
during the progress of the case. Dutton also found the para- 
site in the blood of a child, three years old, a native of the 
Gambia, but in whom no symptoms of illness were present. 
A little later Manson met with a patient in London whose 
svmptoms were so suspicious that on examining his blood 
trypanosomas were detected, and thereby a_ significant 
advance in the clinical recognition of the disease was made. 
