1287 
substrate, also supplies ‘‘enzymosites’,') that is to say a special 
“enzyme food”. The latter supposition will probably be the right 
one, for the real enzymes are in their origin in no way dependent 
‘on their substrates, as we learn from almost every experiment with 
microbes. ”) 
The enzymosites apparently correspond to ABDERHALDEN’s “Bau- 
steine” of the specifie living proteids, that is of the protoplasm. That, 
in case these enzymosites differ, different heredity units or protoplasm 
micells will develop from the mixture of units from which the latter is 
built up, is to be expected. For if we remember in how remarkable 
a way in elective culture experiments with microbes, the thereby 
obtained floras depend on nutrition, we may safely conclude that 
the same will be the case in the subtle world of protoplasm molecules. 
That from the gall-animal no enzymes pass into the plant, is in 
accordance with the fact that foreign exoenzymes commonly do not 
enter living cells. The diastase, which in the distilleries occurs in 
great quantity in the food of yeast, which consists for a great part 
of malt, does not penetrate into the yeast-cell. Experiments purposely 
carried out with other exoenzymes and various kinds of other 
microbes have invariably given the same result. The possibility of 
endoenzymes passing by diffusion from one living cell into another 
is of course wholly excluded”) 
On the other hand, in the range of immunology, facts are known 
which prove that living cells sometimes take up enzymes from their 
surroundings. 
In those cases namely when acquired immunity is hereditary the 
thereby concerned substances must needs belong to the heredity 
units, hence to the enzymes. 
They give evidence that Darwin’s view, according to which the 
“gemmules”” of his pangenesis hypothesis freely move within the 
1) Sitos, food. 
?) Many diastatic bacteria for example produce diastase without the presence of 
amylum in their food. This must be ascertained by a special experiment, amylum 
being the only known reactive on diastase; the literature proves that this has 
sometimes been forgotten by the investigators. 
3) It is not impossible that endoenzymes such as zymase are to some degree 
capable of ordinary diffusion (which is quite another thing than penetrating into 
living protoplasm). Gelatin can slightly penetrate into agar, likewise starch and 
even the carbon of Indian ink. Gold seems able to penetrate into lead. In the 
protoplasm of luminous bacteria no disposition for diffusion is to be observed. 
However the pathological light of Noctiluca miliaris, described by pe QuaTREFAGEs, 
seems to repose on the entering of the photoplasm or luciferase into the cell-sap 
in which the luciferine must then be dissolved, 
