979 



more the drawings of Ogata also show that the process observed 

 in the bone-marrow bears no resemblance whatevei' to Wright's. 

 In other respects their assertions are also clashing. Let us, however, 

 dismiss Ogata's process from further discussion, considering that this 

 worker confined himself to bone-marrow, and let us give our atten- 

 tion more particularly to Wright's publication. 



In the sections examined by myself, and they are many, I have 

 never been able to detect a process in agreement with Wright's 

 conception. Wright may be m.istaken. He may have drawn a far- 

 reaching conclusion from a superficial similarity. I do not think it 

 improbable. The process desci'ibed by me is so perfectly evident 

 that anyone who examines the spleen of a kitten of two weeks, 

 must see it. I, therefore, believe that he has also observed it, but I 

 am positive that it is not a formation of thrombocytes. This assertion 

 is based on the following considerations: 



First and foremost the process is demonstrable with any pi-oper 

 fixation- and staining method, also with those that do not show 

 thrombocytes in any portion of the preparation. Protoplasm 

 filaments are, indeed, vaguely discernible as well as those that are 

 still properly stained. Moreover the thickness of 3 f/, which Wright 

 prescribes for the sections, is as little imperative as his special 

 staining method. As stated above I took the trouble to cut sections 

 of 3 n, but they could not alter my opinion. The diameter of the 

 protoplasm filaments also is many times larger than that of a 

 thrombocyte. 



Did Wright overlook the extrusion of entire degenerating cells 

 just in the large veins (not in the capillaries)? Again, how does 

 Wright account for the thrombocyte-formation when it should appear 

 that also in mammalia the thrombocytes are nucleated cells? This 

 question has not been solved as yet. H. G. Langkmeyer (J 916) e.g. 

 again arrives at this conclusion. In that case the thrombocytes, 

 which, according to Ogata, originate only from the marginal zone 

 (Heidenhain 1907), could not possibly contain any karyoplasm. And 

 would it be likely that the giant-cells ever continue to form throm- 

 bocytes? How then does Wright account for those detached pyknotic 

 nuclei that occur too frequently to be considered as mere casual 

 phenomena? They are lying in the vessels as well as in the spleen pulpa. 



It is true, Wright has reserved some clinical adhesion latterly, 

 e.g. from Hal Downey, Bunting (1909), Selling (1910) and above 

 all from E. F'rank (1915). But histologically this support is not 

 well-founded, and besides highly debatable. It is out of place here 

 to enter into further discussion on this point. 



