( 292 ) 
Converted into fat, and as such appear for a great part in the 
chylevessels. The last is opportune; for as Munk first observed, the 
presence of relatively small quantities of soap in the blood circuit 
is dangerous to life; an intravenous injection of 0.12 gr. of soap 
per kilogr. of the weights of the rabbit already caused death. 
These experiments made it highly probable that already in the 
mucosa of the small intestine the fatty acids combine!) with gly- 
cerine into fat. And the preliminary experiments of EwaLD?) with 
finely minced mucosa of the small intestine have confirmed this 
hypothesis. 
Now as there is no ground for assuming that the soap which is 
absorbed in the large intestine passes without injury into the blood 
it seemed to me not too hazardous to conjecture that the oleic 
acid in the large intestine is also converted into fat. 
To test this hypothesis by observation, we made experiments in 
three directions. 
Ist We examined whether the mucosa of a loop of intestine 
which has been some time filled with a solution of soap shows an 
increase of fat. (As is known, some fat can always be extracted 
from the normal mucosa). 
2nd We examined whether the formation of fat stated under 1“ 
does indeed continue after the intestine has been taken out of the 
body and is left to itself at the temperature of the body. 
3rd We inquired whether the fresh and still warm mucosa of 
the intestine, after having been minced fine and then saturated with 
a solution of soap in which was a little glycerine, was still able 
to convert soap into fat. 
This proved to be really the case. The conversion, however, could 
no longer be observed when the mucosa had previously been heated 
to 80°. Hence this suggests fermentation. 
There can be no doubt, then, that soap resorbed in the large 
intestine is, partially at least, converted into fat in the mucosa. 
IV. Resorption of fat from lipanine-soap emulsion. 
It having thus been established what happens to the soap resorbed in 
the large intestine, we went back to our point cf departure and 
inquired whether, according to our theory, laid down at page 290, 
1) The origin of the glycerine is still uncertain. 
2) C.A. Ewaup. Uber Fettbildung durch die überlebende Darmschleimhaut. Archiv. 
f, Anat. und Physiol. Abth. 1885, Supplem. S. 302, 
