( 696 ) 
circulation of the blood depend only or at least principally on the 
effect on the heart, the pulsations of which are weakened and become 
irregular ; only very large doses are able to paralyse the heart definitely. 
Eject on the intestine. 
Pieces of intestine of cats were suspended in Ringer'’s fluid through 
which O was led, their contractions being graphically registered. 
Then the standard solution was poured into this fluid. The result was 
that paralysis always manifested itself but the doses required to bring 
this about varied a good deal. The largest dosis required was 2 mg. 
to 250 cc. fluid. Stimulation-svmptoms in the beginning could not 
clearly be observed. 
Effect on the mucous membranes and per os. 
On the conjunctiva of a rabbit was put some derrid in substance 
and afterwards in solution; no symptoms manifested themselves. | 
myself put a piece of cotton-wool soaked in 0.2°/, derrid solution 
between my lips and one between cheek and gums. 
After about half an hour I observed a peculiar tingling feeling in 
my lips and a sharp feeling in my throat as if [ continually felt 
inclined to swallow. This sensation continued for some hours. I could 
not observe an aromatic taste as described by Gresnorr, which may 
be accounted for by the fact that he used the root. 
(;RESHOFF states *) that a case of suicide by means of toeba has 
been reported to him in which vomiting and dizziness manifested them- 
selves. Therefore the following experiments were made: A cat was 
given a large quantity of derrid per os through a stomach-tube. 
Within 20 minutes vomiting and diarrhoea manifested themselves, 
followed by disturbances of the equilibrium, with violent dyspnoea. 
In the beginning all reflexes were present. 
There was stimulation of the pilomotores: the hair of back and 
tail stood on end, as with asphyxia; however the mucous membranes 
were a bright red. so that this was not a case of asphyxia. The 
pupils were dilated maximally. After a short time the animal suffered 
itself to be put in all positions; it showed strong saliva-secretion and 
perspiration on the foot-soles. The animal lay on the table quite 
motionless, as if unconscious; the respiration was quickened and 
deepened, the pulse reduced to half its rate. 
1) GresHorr. Med XXIX Batavia. 1900 blz. 175. 
