( 697 ) 
Gradually all symptoms disappeared till at last only incoordinate 
walking remained which at length disappeared as well. After three 
hours the animal looked quite normal again. 
With a following experiment a ligature was put round the pylorus- 
part of the stomach; when the animal had quite recovered from the 
narcosis it was given, per os, a quantity -of derrid equal to that of 
the previous experiment; after 3 hours no symptoms could be observed. 
Now the ligature was removed in narcosis, so that the quantity of 
derrid that was left could get into the intestine. When the animal 
had recovered from this narcosis, we saw the derrid-symptoms mani- 
fest themselves: lieking of the mouth, diarrhoea, vomiting, strong 
secretion of saliva; for the rest of the day it sat quite motionless, 
with drooping head. Afterwards it quite recovered. 
In a third experiment the same ligature was made, and moreover, 
past this ligature, enterostomia was performed in the first part of 
the duodenum; an india-rubber tube protruded from the abdomen. 
When the animal had recovered from the narcosis, a quantity of 
derrid, equal to that of the previous experiments, was poured through 
the tube (of course it could not get into the stomach). Now 10 min. 
after the injection derrid-symptoms manifested themselves: licking of 
the mouth; violent vomitive movements, during which a slimy sub- 
stance was removed; diarrhoea; disturbances of the equilibrium ; 
lying on the back; dyspnoea; decreased reflexes, apparent un- 
„consciousness. After a few hours the animal recovered, till at last all 
symptoms vanished. The intestine was put in its original condition 
again. 
So here we observe the same things as during the other experiments : 
effect on the central nervous system, respiration and circulation ; 
especially manifest are coordination-disturbances, vomiting, diarrhoea 
and symptoms coming from the sympathetic nervous system: pupil- 
dilatation, intensified secretion of saliva and perspiration, besides sti- 
mulation of the pilomotores. 
Local effect of derrid. 
After subcutaneous injections in frogs, white mice, rabbits and 
guinea-pigs we never saw any reaction manifest itself in the place 
of injection. Only in frogs a change could be observed in the muscles, 
which presented itself as a white colouring of the muscle in question ; 
the muscle looked as if boiled and was not electrically sensitive 
any more. So the local effect may be termed very slight. 
